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Literature DB >> 2484599

Role of metal ions in oxidant cell injury.

Abstract

This paper represents a short review of recent data on the molecular mechanism(s) of H2O2 cytotoxicity. The role of metal ions has been discussed in light of their ability to drive a reaction of the Fenton type. Hydroxyl radicals play a key role in mediating the deleterious effects of the oxidant, although these species do not seem to directly produce the lethal lesions. It still remains unclear whether or not DNA represents a critical target for H2O2-induced cytotoxicity.

Entities: Chemical Disease

Mesh：

Substances：
Metals
Hydrogen Peroxide

Year: 1989 PMID： 2484599 DOI： 10.1007/bf02917264

Source DB: PubMed Journal: Biol Trace Elem Res ISSN： 0163-4984 Impact factor: 3.738

16 in total

1. Action of hydrogen peroxide on human fibroblast in culture.

Authors: M E Hoffmann; R Meneghini
Journal: Photochem Photobiol Date: 1979-07 Impact factor: 3.421

2. Induction and repair of DNA single-strand breaks in EM9 mutant CHO cells treated with hydrogen peroxide.

Authors: O Cantoni; D Murray; R E Meyn
Journal: Chem Biol Interact Date: 1987 Impact factor: 5.192

3. Calcium chelator Quin 2 prevents hydrogen-peroxide-induced DNA breakage and cytotoxicity.

Authors: O Cantoni; P Sestili; F Cattabeni; G Bellomo; S Pou; M Cohen; P Cerutti
Journal: Eur J Biochem Date: 1989-06-15

4. Correlation between cytotoxic effect of hydrogen peroxide and the yield of DNA strand breaks in cells of different species.

Authors: M E Hoffmann; A C Mello-Filho; R Meneghini
Journal: Biochim Biophys Acta Date: 1984-04-05

8. Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals in the presence of copper salts: a physiologically significant reaction?

Authors: D A Rowley; B Halliwell
Journal: Arch Biochem Biophys Date: 1983-08 Impact factor: 4.013

9. Effect of 3-aminobenzamide on DNA strand-break rejoining and cytotoxicity in CHO cells treated with hydrogen peroxide.

Authors: O Cantoni; D Murray; R E Meyn
Journal: Biochim Biophys Acta Date: 1986-06-20

Role of metal ions in oxidant cell injury.

1. Action of hydrogen peroxide on human fibroblast in culture.

2. Induction and repair of DNA single-strand breaks in EM9 mutant CHO cells treated with hydrogen peroxide.

3. Calcium chelator Quin 2 prevents hydrogen-peroxide-induced DNA breakage and cytotoxicity.

4. Correlation between cytotoxic effect of hydrogen peroxide and the yield of DNA strand breaks in cells of different species.

5. In vivo formation of single-strand breaks in DNA by hydrogen peroxide is mediated by the Haber-Weiss reaction.

6. Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron.

7. Effects of oxygen stress on membrane functions in Escherichia coli: role of HPI catalase.

8. Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals in the presence of copper salts: a physiologically significant reaction?

9. Effect of 3-aminobenzamide on DNA strand-break rejoining and cytotoxicity in CHO cells treated with hydrogen peroxide.

10. Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical.

Review 1. A free-radical hypothesis for the instability and evolution of genotype and phenotype in vitro.

2. The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenine.