Literature DB >> 6712613

Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron.

A C Mello Filho, M E Hoffmann, R Meneghini.   

Abstract

Phenanthroline, a strong iron chelator, prevents both the formation of DNA single-strand breaks and the killing of mouse cells produced by H2O2. These results, taken together with our previous findings, indicate that the DNA damage is produced by hydroxyl radicals formed when H2O2 reacts with chromatin-bound Fe2+ and that this damage is responsible for the killing effect.

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Year:  1984        PMID： 6712613      PMCID： PMC1153333          DOI： 10.1042/bj2180273

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

Review 1.  Superoxide dismutases.

Authors:  I Fridovich
Journal:  Annu Rev Biochem       Date:  1975       Impact factor: 23.643

2.  Gaps in DNA synthesized by ultraviolet light-irradiated WI38 human cells.

Authors:  R Meneghini
Journal:  Biochim Biophys Acta       Date:  1976-04-02

3.  Action of hydrogen peroxide on human fibroblast in culture.

Authors:  M E Hoffmann; R Meneghini
Journal:  Photochem Photobiol       Date:  1979-07       Impact factor: 3.421

4.  Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species.

Authors:  J M Tolmasoff; T Ono; R G Cutler
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205

5.  Mutagenicity of oxygen free radicals.

Authors:  C S Moody; H M Hassan
Journal:  Proc Natl Acad Sci U S A       Date:  1982-05       Impact factor: 11.205

6.  Free radicals and inflammation: protection of synovial fluid by superoxide dismutase.

Authors:  J M McCord
Journal:  Science       Date:  1974-08-09       Impact factor: 47.728

7.  The damaging action of hydrogen peroxide on DNA of human fibroblasts is mediated by a non-dialyzable compound.

Authors:  R Meneghini; M E Hoffmann
Journal:  Biochim Biophys Acta       Date:  1980-06-27

8.  Neuronal cell damage in the brain: possible involvement of oxidative mechanisms.

Authors:  B K Siesjö; S Rehncrona; D Smith
Journal:  Acta Physiol Scand Suppl       Date:  1980

9.  Hydrogen peroxide causes the fatal injury to human fibroblasts exposed to oxygen radicals.

Authors:  R H Simon; C H Scoggin; D Patterson
Journal:  J Biol Chem       Date:  1981-07-25       Impact factor: 5.157

10.  Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical.

Authors:  J E Repine; R B Fox; E M Berger
Journal:  J Biol Chem       Date:  1981-07-25       Impact factor: 5.157
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  51 in total

1.  Induction/repair of strand breakage in mature and nascent DNA of cultured Chinese hamster ovary cells exposed to hydrogen peroxide.

Authors:  O Cantoni; M Fiorani; M Mugnaini; F Cattabeni
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

2.  The spectrum of mutations generated by passage of a hydrogen peroxide damaged shuttle vector plasmid through a mammalian host.

Authors:  E C Moraes; S M Keyse; M Pidoux; R M Tyrrell
Journal:  Nucleic Acids Res       Date:  1989-10-25       Impact factor: 16.971

3.  Role of hydrogen peroxide in the cytotoxicity of the xanthine/xanthine oxidase system.

Authors:  E M Link; P A Riley
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857

4.  Substantial DNA damage from submicromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coli.

Authors:  Sunny Park; Xiaojun You; James A Imlay
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-20       Impact factor: 11.205

5.  Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids.

Authors:  M Grootveld; B Halliwell
Journal:  Biochem J       Date:  1986-07-15       Impact factor: 3.857

6.  Potentiation by sulfide of hydrogen peroxide-induced killing of Escherichia coli.

Authors:  E H Berglin; J Carlsson
Journal:  Infect Immun       Date:  1985-09       Impact factor: 3.441

7.  Effect of bacitracin on erythroid differentiation of MEL cells.

Authors:  M Foresti; L Migliore
Journal:  Cell Biol Toxicol       Date:  1993 Oct-Dec       Impact factor: 6.691

8.  Oxidative stress by menadione affects cellular copper and iron homeostasis.

Authors:  M Calderaro; E A Martins; R Meneghini
Journal:  Mol Cell Biochem       Date:  1993-09-08       Impact factor: 3.396

9.  Endonuclease-induced DNA damage and cell death in oxidant injury to renal tubular epithelial cells.

Authors:  N Ueda; S V Shah
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

10.  Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Authors:  Douglas B Kell
Journal:  BMC Med Genomics       Date:  2009-01-08       Impact factor: 3.063
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