Literature DB >> 24845790

The role of necrotic cell death in the pathogenesis of immune mediated nephropathies.

Neelakshi R Jog1, Roberto Caricchio2.   

Abstract

Necrosis, an inflammatory form of cell death, has been considered to be an accidental death and/or cell death due to injury. However, the literature in the last decade has established that necrosis is a regulated form of cell death, and that inhibition of specific molecular pathways leading to necrosis can block it and reduce inflammation. Since necrotic lesions are observed in several immune mediated human pathologies, in this review we will discuss the impact that this form of programmed cellular demise has in the pathology of immune mediated nephropathies.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Autoimmunity; Cell death; Necrosis; Nephritis

Mesh：

Substances：

Year:  2014        PMID： 24845790      PMCID： PMC4348018          DOI： 10.1016/j.clim.2014.05.002

Source DB:  PubMed          Journal:  Clin Immunol        ISSN： 1521-6616            Impact factor:   3.969


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