| Literature DB >> 24844449 |
Khalid Mohammed Khan1, Fazal Rahim2, Abdul Wadood3, Naveen Kosar2, Muhammad Taha4, Salima Lalani5, Aisha Khan2, Muhammad Imran Fakhri5, Muhammad Junaid3, Wajid Rehman2, Momin Khan6, Shahnaz Perveen7, Muhammad Sajid8, M Iqbal Choudhary5.
Abstract
In our effort directed toward the discovery of new anti-diabetic agent for the treatment of diabetes, a library of biscoumarin derivative 1-18 was synthesized and evaluated for α-glucosidase inhibitory potential. All eighteen (18) compounds displayed assorted α-glucosidase activity with IC50 values 16.5-385.9 μM, if compared with the standard acarbose (IC50 = 906 ± 6.387 μM). In addition, molecular docking studies were carried out to explore the binding interactions of biscoumarin derivatives with the enzyme. This study has identified a new class of potent α-glucosidase inhibitors.Entities:
Keywords: Biscoumarin; Molecular docking; α-Glucosidase inhibition
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Year: 2014 PMID： 24844449 DOI： 10.1016/j.ejmech.2014.05.010
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514