Literature DB >> 24843870

Vitamin A and dendritic cell differentiation.

Marieke R Beijer, Georg Kraal, Joke M M den Haan.   

Abstract

Vitamin A and its active metabolite retinoic acid are essential for the development and function of many tissues including the immune system. The induction of mucosal homing receptors on T and B cells by mucosal dendritic cells (DC) depends on the presence of vitamin A. Recent studies indicate that also the differentiation of CD11b+ DC subsets in the mucosa as well as the spleen depend on vitamin A signalling. As CD11b+ DC subsets exert non-redundant functions in anti-bacterial and anti-fungal immune responses, defects in CD11b+ DC differentiation will contribute to the clinical problems observed during vitamin A deficiency.

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Year:  2014        PMID： 24843870      PMCID： PMC3992046          DOI： 10.1111/imm.12228

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


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