Julia L Finkelstein1, Susannah Colt1, Alexander J Layden1,2, Jesse T Krisher1, Anna M Stewart-Ibarra3, Mark Polhemus3, Efraín Beltrán-Ayala4,5, Julia M Tedesco1, Washington B Cárdenas6, Timothy Endy3, Saurabh Mehta1. 1. Division of Nutritional Sciences, Cornell University, Ithaca, New York. 2. University of Pittsburgh School of Medicine, Pennyslvania. 3. Department of Medicine and Center for Global Health and Translational Science, SUNY Upstate Medical University, Syracuse, New York. 4. Ministry of Health, Machala, El Oro, Ecuador. 5. Department of Medicine, Technical University of Machala, El Oro, Ecuador. 6. Escuela Superior Politécnica del Litoral, Laboratorio para Investigaciones Biomédicas, Guayaquil, Ecuador.
Abstract
BACKGROUND: Micronutrients are known to modulate host immunity, and there is limited literature on this association in the context of dengue virus infection (DENV). METHODS: Using a nested case-control design in a surveillance program, we measured the following: anthropometry; nutritional biomarkers including serum ferritin, soluble transferrin receptor, retinol-binding protein (RBP), 25-hydroxy vitamin D, folate, and vitamin B12; and a panel of immune response markers. We then compared these measures across 4 illness categories: healthy control, nonfebrile DENV, other febrile illness (OFI), and apparent DENV using multivariate polytomous logistic regression models. RESULTS: Among 142 participants, serum ferritin (ng/mL) was associated with apparent DENV compared to healthy controls (odds ratio [OR], 2.66; confidence interval [CI], 1.53-4.62; P = .001), and RBP concentrations (µmol/L) were associated with apparent DENV (OR, 0.03; CI, 0.00-0.30; P = .003) and OFI (OR, 0.02; CI, 0.00-0.24; P = .003). In a subset of 71 participants, interleukin-15 levels (median fluorescent intensity) were positively associated with apparent DENV (OR, 1.09; CI, 1.03-1.14; P = .001) and negatively associated with nonfebrile DENV (OR, 0.89; CI, 0.80-0.99; P = .03) compared to healthy controls. CONCLUSIONS: After adjusting for the acute-phase response, serum ferritin and RBP concentrations were associated with apparent DENV and may represent biomarkers of clinical importance in the context of dengue illness.
BACKGROUND: Micronutrients are known to modulate host immunity, and there is limited literature on this association in the context of dengue virus infection (DENV). METHODS: Using a nested case-control design in a surveillance program, we measured the following: anthropometry; nutritional biomarkers including serum ferritin, soluble transferrin receptor, retinol-binding protein (RBP), 25-hydroxy vitamin D, folate, and vitamin B12; and a panel of immune response markers. We then compared these measures across 4 illness categories: healthy control, nonfebrile DENV, other febrile illness (OFI), and apparent DENV using multivariate polytomous logistic regression models. RESULTS: Among 142 participants, serum ferritin (ng/mL) was associated with apparent DENV compared to healthy controls (odds ratio [OR], 2.66; confidence interval [CI], 1.53-4.62; P = .001), and RBP concentrations (µmol/L) were associated with apparent DENV (OR, 0.03; CI, 0.00-0.30; P = .003) and OFI (OR, 0.02; CI, 0.00-0.24; P = .003). In a subset of 71 participants, interleukin-15 levels (median fluorescent intensity) were positively associated with apparent DENV (OR, 1.09; CI, 1.03-1.14; P = .001) and negatively associated with nonfebrile DENV (OR, 0.89; CI, 0.80-0.99; P = .03) compared to healthy controls. CONCLUSIONS: After adjusting for the acute-phase response, serum ferritin and RBP concentrations were associated with apparent DENV and may represent biomarkers of clinical importance in the context of dengue illness.
Authors: Cornelia A M van de Weg; Ralph M H G Huits; Cláudio S Pannuti; Rosalba M Brouns; Riemsdijk W A van den Berg; Henk-Jan van den Ham; Byron E E Martina; Albert D M E Osterhaus; Mihai G Netea; Joost C M Meijers; Eric C M van Gorp; Esper G Kallas Journal: PLoS Negl Trop Dis Date: 2014-10-09
Authors: Anna M Stewart-Ibarra; Sadie J Ryan; Aileen Kenneson; Christine A King; Mark Abbott; Arturo Barbachano-Guerrero; Efraín Beltrán-Ayala; Mercy J Borbor-Cordova; Washington B Cárdenas; Cinthya Cueva; Julia L Finkelstein; Christina D Lupone; Richard G Jarman; Irina Maljkovic Berry; Saurabh Mehta; Mark Polhemus; Mercy Silva; Timothy P Endy Journal: Am J Trop Med Hyg Date: 2018-03-01 Impact factor: 2.345
Authors: Nguyen Lam Vuong; Phung Khanh Lam; Damien Keng Yen Ming; Huynh Thi Le Duyen; Nguyet Minh Nguyen; Dong Thi Hoai Tam; Kien Duong Thi Hue; Nguyen Vv Chau; Ngoun Chanpheaktra; Lucy Chai See Lum; Ernesto Pleités; Cameron P Simmons; Kerstin D Rosenberger; Thomas Jaenisch; David Bell; Nathalie Acestor; Christine Halleux; Piero L Olliaro; Bridget A Wills; Ronald B Geskus; Sophie Yacoub Journal: Elife Date: 2021-06-22 Impact factor: 8.140