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Literature DB >> 24841289

Small-molecule SMAC mimetics as new cancer therapeutics.

Longchuan Bai¹, David C Smith², Shaomeng Wang³.

Abstract

Apoptosis is a tightly regulated cellular process and faulty regulation of apoptosis is a hallmark of human cancers. Targeting key apoptosis regulators with the goal to restore apoptosis in tumor cells has been pursued as a new cancer therapeutic strategy. XIAP, cIAP1, and cIAP2, members of inhibitor of apoptosis (IAP) proteins, are critical regulators of cell death and survival and are attractive targets for new cancer therapy. The SMAC/DIABLO protein is an endogenous antagonist of XIAP, cIAP1, and cIAP2. In the last decade, intense research efforts have resulted in the design and development of several small-molecule SMAC mimetics now in clinical trials for cancer treatment. In this review, we will discuss the roles of XIAP, cIAP1, and cIAP2 in regulation of cell death and survival, and the design and development of small-molecule SMAC mimetics as novel cancer treatments.

Entities: CellLine Chemical Disease Gene Species

Keywords: Apoptosis; Inhibitors; SMAC mimetics

Mesh：

Substances：

Year: 2014 PMID： 24841289 PMCID： PMC4247261 DOI： 10.1016/j.pharmthera.2014.05.007

Source DB: PubMed Journal: Pharmacol Ther ISSN： 0163-7258 Impact factor: 12.310

142 in total

1. Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer.

Authors: Sean P Dineen; Christina L Roland; Rachel Greer; Juliet G Carbon; Jason E Toombs; Puja Gupta; Nabeel Bardeesy; Haizhou Sun; Noelle Williams; John D Minna; Rolf A Brekken
Journal: Cancer Res Date: 2010-03-23 Impact factor: 12.701

2. Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis.

Authors: Jie Zhao; Siriporn Jitkaew; Zhenyu Cai; Swati Choksi; Qiuning Li; Ji Luo; Zheng-Gang Liu
Journal: Proc Natl Acad Sci U S A Date: 2012-03-15 Impact factor: 11.205

3. Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors.

Authors: Eugene Varfolomeev; Tatiana Goncharov; Heather Maecker; Kerry Zobel; László G Kömüves; Kurt Deshayes; Domagoj Vucic
Journal: Sci Signal Date: 2012-03-20 Impact factor: 8.192

4. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.

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Journal: Cell Date: 2000-07-07 Impact factor: 41.582

Review 5. Cell signaling by receptor tyrosine kinases.

Authors: Mark A Lemmon; Joseph Schlessinger
Journal: Cell Date: 2010-06-25 Impact factor: 41.582

6. Smac mimetic compounds potentiate interleukin-1beta-mediated cell death.

Authors: Herman H Cheung; Shawn T Beug; Martine St Jean; Audrey Brewster; N Lynn Kelly; Shaomeng Wang; Robert G Korneluk
Journal: J Biol Chem Date: 2010-10-18 Impact factor: 5.157

7. CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration.

Authors: Juanita Lopez; Sidonie Wicky John; Tencho Tenev; Gilles J P Rautureau; Mark G Hinds; Floriana Francalanci; Rebecca Wilson; Meike Broemer; Massimo M Santoro; Catherine L Day; Pascal Meier
Journal: Mol Cell Date: 2011-05-05 Impact factor: 17.970

8. Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.

Authors: Qi-Heng Yang; Chunying Du
Journal: J Biol Chem Date: 2004-02-11 Impact factor: 5.157

9. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.

Authors: Young Sik Cho; Sreerupa Challa; David Moquin; Ryan Genga; Tathagat Dutta Ray; Melissa Guildford; Francis Ka-Ming Chan
Journal: Cell Date: 2009-06-12 Impact factor: 41.582

10. cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).

Authors: Mathieu J M Bertrand; Saskia Lippens; An Staes; Barbara Gilbert; Ria Roelandt; Jelle De Medts; Kris Gevaert; Wim Declercq; Peter Vandenabeele
Journal: PLoS One Date: 2011-09-12 Impact factor: 3.240

68 in total

1. Induction and Detection of Necroptotic Cell Death in Mammalian Cell Culture.

Authors: Mikhail Chesnokov; Imran Khan; Ilana Chefetz
Journal: Methods Mol Biol Date: 2021

2. Hyperbaric Oxygen Preconditioning Protects Against Cerebral Ischemia/Reperfusion Injury by Inhibiting Mitochondrial Apoptosis and Energy Metabolism Disturbance.

Authors: Shun-Da Wang; Ying-Ying Fu; Xin-Yuan Han; Zhi-Jun Yong; Qing Li; Zhen Hu; Zhen-Guo Liu
Journal: Neurochem Res Date: 2021-01-16 Impact factor: 3.996

Review 3. Apoptosis and apoptotic body: disease message and therapeutic target potentials.

Authors: Xuebo Xu; Yueyang Lai; Zi-Chun Hua
Journal: Biosci Rep Date: 2019-01-18 Impact factor: 3.840

4. Birinapant (TL32711) Improves Responses to GEM/AZD7762 Combination Therapy in Triple-negative Breast Cancer Cell Lines.

Authors: Dong-Joon Min; Siping He; Jeffrey E Green
Journal: Anticancer Res Date: 2016-06 Impact factor: 2.480

5. Proteomics for cancer drug design.

Authors: Amanda Haymond; Justin B Davis; Virginia Espina
Journal: Expert Rev Proteomics Date: 2019-08-04 Impact factor: 3.940

Review 6. Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.

Authors: Michelle R Arkin; Yinyan Tang; James A Wells
Journal: Chem Biol Date: 2014-09-18

7. Physiologically-based pharmacokinetic and pharmacodynamic models for gemcitabine and birinapant in pancreatic cancer xenografts.

Authors: Xu Zhu; Sheryl Trueman; Robert M Straubinger; William J Jusko
Journal: J Pharmacokinet Pharmacodyn Date: 2018-08-01 Impact factor: 2.745