Wenbin Guo1, Feng Liu2, Guanglei Xun3, Maorong Hu4, Xiaofeng Guo5, Changqing Xiao6, Huafu Chen2, Jindong Chen7, Jingping Zhao8. 1. Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China; Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China. 2. Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China. 3. Shandong Mental Health Center, Jinan, Shandong 250014, China. 4. Mental Hospital of Nanchang University & Mental Health Center of Jiangxi Province, Nanchang, Jiangxi 330029, China. 5. Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China. 6. Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China. 7. Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China. Electronic address: chenjd269@163.com. 8. Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address: edsgwb@126.com.
Abstract
BACKGROUND: Abnormalities of white matter integrity in frontal and limbic regions have been postulated to play a key role in the pathophysiology of geriatric depression. However, there is no diffusion tensor imaging (DTI) study in patients with first-episode, drug-naive, late-onset depression (LOD). The aim of this study was to investigate whole-brain fractional anisotropy (FA) difference between patients with LOD and healthy controls without a previously determined region of interest. METHODS: The sample included 15 patients with first-episode, drug-naive LOD and 15 age-, sex-, and education-matched healthy controls. The tract-based spatial statistics (TBSS) method was employed to analyze the DTI data. RESULTS: Lower FA in the white matter of bilateral parahippocampal gyrus was observed in patients with LOD relative to healthy controls by voxel-wise statistics with the TBSS method. Patients did not have higher FA values in any brain regions compared to healthy controls. There was no correlation between the abnormal FA value in bilateral parahippocampal gyrus and depression severity or related factors. LIMITATIONS: The present study should be considered preliminary due to relatively small sample size. CONCLUSIONS: Our findings suggest that loss of white matter integrity in parahippocampal gyrus may be associated with the pathophysiology of LOD, and thus highlight the limbic contribution to the pathophysiology of LOD.
BACKGROUND:Abnormalities of white matter integrity in frontal and limbic regions have been postulated to play a key role in the pathophysiology of geriatric depression. However, there is no diffusion tensor imaging (DTI) study in patients with first-episode, drug-naive, late-onset depression (LOD). The aim of this study was to investigate whole-brain fractional anisotropy (FA) difference between patients with LOD and healthy controls without a previously determined region of interest. METHODS: The sample included 15 patients with first-episode, drug-naive LOD and 15 age-, sex-, and education-matched healthy controls. The tract-based spatial statistics (TBSS) method was employed to analyze the DTI data. RESULTS: Lower FA in the white matter of bilateral parahippocampal gyrus was observed in patients with LOD relative to healthy controls by voxel-wise statistics with the TBSS method. Patients did not have higher FA values in any brain regions compared to healthy controls. There was no correlation between the abnormal FA value in bilateral parahippocampal gyrus and depression severity or related factors. LIMITATIONS: The present study should be considered preliminary due to relatively small sample size. CONCLUSIONS: Our findings suggest that loss of white matter integrity in parahippocampal gyrus may be associated with the pathophysiology of LOD, and thus highlight the limbic contribution to the pathophysiology of LOD.
Authors: Nikolaos Koutsouleris; Eva M Meisenzahl; Stefan Borgwardt; Anita Riecher-Rössler; Thomas Frodl; Joseph Kambeitz; Yanis Köhler; Peter Falkai; Hans-Jürgen Möller; Maximilian Reiser; Christos Davatzikos Journal: Brain Date: 2015-05-01 Impact factor: 13.501
Authors: Benoit H Mulsant; Aristotle N Voineskos; Neda Rashidi-Ranjbar; Tarek K Rajji; Colin Hawco; Sanjeev Kumar; Nathan Herrmann; Linda Mah; Alastair J Flint; Corinne E Fischer; Meryl A Butters; Bruce G Pollock; Erin W Dickie; Christopher R Bowie; Matan Soffer Journal: Neuropsychopharmacology Date: 2022-04-11 Impact factor: 7.853