Literature DB >> 24833583

The role of macromolecular damage in aging and age-related disease.

Arlan G Richardson1, Eric E Schadt2.   

Abstract

Several decades of research have shown that macromolecular damage increases with age and that damage to protein, DNA, lipids, and other macromolecular components appears to be important factors in specific age-related diseases. The strongest evidence that macromolecular damage is a causative factor in aging comes from studies using manipulations that increase life span. However, it is currently unclear whether damage to macromolecules plays a role in the actual processes of aging. In other words, is macromolecular damage driven by aging or is it that damage to a key molecular component directly causes aging?
© The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  DNA oxidative damage; Oxidative stress.; Protein oxidative damage

Mesh：

Substances：

Year:  2014        PMID： 24833583     DOI： 10.1093/gerona/glu056

Source DB:  PubMed          Journal:  J Gerontol A Biol Sci Med Sci        ISSN： 1079-5006            Impact factor:   6.053


  19 in total

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4.  Primary microcephaly gene MCPH1 shows a novel molecular biomarker of human renal carcinoma and is regulated by miR-27a.

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5.  Aging-Related Reduced Expression of CXCR4 on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects.

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6.  Calorie Restriction and Aging in Humans.

Authors:  Emily W Flanagan; Jasper Most; Jacob T Mey; Leanne M Redman
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7.  Telomeric aging: mitotic clock or stress indicator?

Authors:  Alexander K Koliada; Dmitry S Krasnenkov; Alexander M Vaiserman
Journal:  Front Genet       Date:  2015-03-16       Impact factor: 4.599

8.  Circulating cell-free DNA, telomere length and bilirubin in the Vienna Active Ageing Study: exploratory analysis of a randomized, controlled trial.

Authors:  Anela Tosevska; Bernhard Franzke; Marlene Hofmann; Immina Vierheilig; Barbara Schober-Halper; Stefan Oesen; Oliver Neubauer; Barbara Wessner; Karl-Heinz Wagner
Journal:  Sci Rep       Date:  2016-12-01       Impact factor: 4.379

9.  Circulating Proteomic Signatures of Chronological Age.

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Journal:  J Gerontol A Biol Sci Med Sci       Date:  2014-08-14       Impact factor: 6.053

Review 10.  Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention.

Authors:  Xudong Zhu; Zhiyang Chen; Weiyan Shen; Gang Huang; John M Sedivy; Hu Wang; Zhenyu Ju
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