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Literature DB >> 24832444

Toxoplasma's arms race with the host interferon response: a ménage à trois of ROPs.

Abstract

The Toxoplasma gondii virulence factors ROP5 and ROP18 both target immunity-related GTPases (IRGs) to evade immunity. In this issue of Cell Host & Microbe, Etheridge et al. (2014) identify a third virulence factor, ROP17, which forms a complex and synergizes with ROP5/ROP18 to fully disable the IRG system of antiparasite defense.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2014 PMID： 24832444 PMCID： PMC4083399 DOI： 10.1016/j.chom.2014.05.002

Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023

10 in total

1. Polymorphic secreted kinases are key virulence factors in toxoplasmosis.

Authors: J P J Saeij; J P Boyle; S Coller; S Taylor; L D Sibley; E T Brooke-Powell; J W Ajioka; J C Boothroyd
Journal: Science Date: 2006-12-15 Impact factor: 47.728

2. Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence.

Authors: Sarah J Fentress; Michael S Behnke; Ildiko R Dunay; Mona Mashayekhi; Leah M Rommereim; Barbara A Fox; David J Bzik; Gregory A Taylor; Benjamin E Turk; Cheryl F Lichti; R Reid Townsend; Wei Qiu; Raymond Hui; Wandy L Beatty; L David Sibley
Journal: Cell Host Microbe Date: 2010-12-16 Impact factor: 21.023

3. Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence.

Authors: Michael L Reese; Gusti M Zeiner; Jeroen P J Saeij; John C Boothroyd; Jon P Boyle
Journal: Proc Natl Acad Sci U S A Date: 2011-03-21 Impact factor: 11.205

4. Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages.

Authors: Yanlin Zhao; David J P Ferguson; Douglas C Wilson; Jonathan C Howard; L David Sibley; George S Yap
Journal: J Immunol Date: 2009-03-15 Impact factor: 5.422

5. The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice.

Authors: Ronald D Etheridge; Aditi Alaganan; Keliang Tang; Hua Jane Lou; Benjamin E Turk; L David Sibley
Journal: Cell Host Microbe Date: 2014-05-14 Impact factor: 21.023

6. The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18.

Authors: Michael S Behnke; Sarah J Fentress; Mona Mashayekhi; Lucy X Li; Gregory A Taylor; L David Sibley
Journal: PLoS Pathog Date: 2012-11-08 Impact factor: 6.823

7. Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii.

Authors: Tobias Steinfeldt; Stephanie Könen-Waisman; Lan Tong; Nikolaus Pawlowski; Tobias Lamkemeyer; L David Sibley; Julia P Hunn; Jonathan C Howard
Journal: PLoS Biol Date: 2010-12-21 Impact factor: 8.029

8. A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins.

Authors: Martin C Fleckenstein; Michael L Reese; Stephanie Könen-Waisman; John C Boothroyd; Jonathan C Howard; Tobias Steinfeldt
Journal: PLoS Biol Date: 2012-07-10 Impact factor: 8.029

9. The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage.

Authors: Cemalettin Bekpen; Julia P Hunn; Christoph Rohde; Iana Parvanova; Libby Guethlein; Diane M Dunn; Eva Glowalla; Maria Leptin; Jonathan C Howard
Journal: Genome Biol Date: 2005-10-31 Impact factor: 13.583

10. Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse.

Authors: Jingtao Lilue; Urs Benedikt Müller; Tobias Steinfeldt; Jonathan C Howard
Journal: Elife Date: 2013-10-29 Impact factor: 8.140