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Literature DB >> 17170306

Polymorphic secreted kinases are key virulence factors in toxoplasmosis.

J P J Saeij¹, J P Boyle, S Coller, S Taylor, L D Sibley, E T Brooke-Powell, J W Ajioka, J C Boothroyd.

Abstract

The majority of known Toxoplasma gondii isolates from Europe and North America belong to three clonal lines that differ dramatically in their virulence, depending on the host. To identify the responsible genes, we mapped virulence in F(1) progeny derived from crosses between type II and type III strains, which we introduced into mice. Five virulence (VIR) loci were thus identified, and for two of these, genetic complementation showed that a predicted protein kinase (ROP18 and ROP16, respectively) is the key molecule. Both are hypervariable rhoptry proteins that are secreted into the host cell upon invasion. These results suggest that secreted kinases unique to the Apicomplexa are crucial in the host-pathogen interaction.

Entities: Disease Species

Mesh：

Substances：

Year: 2006 PMID： 17170306 PMCID： PMC2646183 DOI： 10.1126/science.1133690

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

24 in total

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Authors: T Lehmann; C R Blackston; S F Parmley; J S Remington; J P Dubey
Journal: J Parasitol Date: 2000-10 Impact factor: 1.276

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Journal: Science Date: 2003-01-17 Impact factor: 47.728

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Journal: J Parasitol Date: 1992-10 Impact factor: 1.276

4. Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondii.

Authors: Peter J Bradley; Chris Ward; Stephen J Cheng; David L Alexander; Susan Coller; Graham H Coombs; Joe Dan Dunn; David J Ferguson; Sanya J Sanderson; Jonathan M Wastling; John C Boothroyd
Journal: J Biol Chem Date: 2005-07-07 Impact factor: 5.157

Review 5. Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host.

Authors: Jeroen P J Saeij; Jon P Boyle; John C Boothroyd
Journal: Trends Parasitol Date: 2005-10

6. Unbiased estimation of the rates of synonymous and nonsynonymous substitution.

Authors: W H Li
Journal: J Mol Evol Date: 1993-01 Impact factor: 2.395

7. Contribution of interleukin-12 (IL-12) and the CD28/B7 and CD40/CD40 ligand pathways to the development of a pathological T-cell response in IL-10-deficient mice.

Authors: Ulrike Wille; Eric N Villegas; Linden Craig; Robert Peach; Christopher A Hunter
Journal: Infect Immun Date: 2002-12 Impact factor: 3.441

8. Determination of genotypes of Toxoplasma gondii strains isolated from patients with toxoplasmosis.

Authors: D K Howe; S Honoré; F Derouin; L D Sibley
Journal: J Clin Microbiol Date: 1997-06 Impact factor: 5.948

9. Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease.

Authors: D K Howe; L D Sibley
Journal: J Infect Dis Date: 1995-12 Impact factor: 5.226

10. Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype.

Authors: Paul M Robben; Dana G Mordue; Steven M Truscott; Kiyoshi Takeda; Shizuo Akira; L David Sibley
Journal: J Immunol Date: 2004-03-15 Impact factor: 5.422

263 in total

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Authors: Eric Y Denkers; David J Bzik; Barbara A Fox; Barbara A Butcher
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4. A novel benzodioxole-containing inhibitor of Toxoplasma gondii growth alters the parasite cell cycle.

Authors: Edwin Kamau; Tracy Meehan; Mark D Lavine; Gustavo Arrizabalaga; Gabriela Mustata Wilson; Jon Boyle
Journal: Antimicrob Agents Chemother Date: 2011-09-26 Impact factor: 5.191

Review 5. Unifying themes in microbial associations with animal and plant hosts described using the gene ontology.

Authors: Trudy Torto-Alalibo; Candace W Collmer; Michelle Gwinn-Giglio; Magdalen Lindeberg; Shaowu Meng; Marcus C Chibucos; Tsai-Tien Tseng; Jane Lomax; Bryan Biehl; Amelia Ireland; David Bird; Ralph A Dean; Jeremy D Glasner; Nicole Perna; Joao C Setubal; Alan Collmer; Brett M Tyler
Journal: Microbiol Mol Biol Rev Date: 2010-12 Impact factor: 11.056

6. A Human Proteome Array Approach to Identifying Key Host Proteins Targeted by Toxoplasma Kinase ROP18.

Authors: Zhaoshou Yang; Yongheng Hou; Taofang Hao; Hee-Sool Rho; Jun Wan; Yizhao Luan; Xin Gao; Jianping Yao; Aihua Pan; Zhi Xie; Jiang Qian; Wanqin Liao; Heng Zhu; Xingwang Zhou
Journal: Mol Cell Proteomics Date: 2017-01-13 Impact factor: 5.911

7. Hammondia hammondi, an avirulent relative of Toxoplasma gondii, has functional orthologs of known T. gondii virulence genes.

Authors: Katelyn A Walzer; Yaw Adomako-Ankomah; Rachel A Dam; Daland C Herrmann; Gereon Schares; Jitender P Dubey; Jon P Boyle
Journal: Proc Natl Acad Sci U S A Date: 2013-04-15 Impact factor: 11.205