Junichiro Sakamoto1, Akiko Imaizumi2, Yoshinori Sasaki3, Takashi Kamio4, Mamoru Wakoh5, Mika Otonari-Yamamoto6, Tsukasa Sano7. 1. Oral and Maxillofacial Radiology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan; Oral and Maxillofacial Radiology, Graduate School, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan. Electronic address: sakajun.orad@tmd.ac.jp. 2. Oral and Maxillofacial Radiology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan. Electronic address: aimaizumi@tdc.ac.jp. 3. Oral and Maxillofacial Radiology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan. Electronic address: sasakiyoshinori@tdc.ac.jp. 4. Oral and Maxillofacial Radiology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan. Electronic address: kamio@tdc.ac.jp. 5. Oral and Maxillofacial Radiology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan. Electronic address: wakoh@tdc.ac.jp. 6. Oral and Maxillofacial Radiology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan. Electronic address: myamamoto@tdc.ac.jp. 7. Oral and Maxillofacial Radiology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan; Division of Radiology, Dept. of Oral Diagnostic Sciences, Showa University School of Dentistry, 2-1-1 Kitasenzoku, Ohta-ku, Tokyo 145-8515, Japan. Electronic address: tssano@dent.showa-u.ac.jp.
Abstract
PURPOSE: To evaluate the use of the intravoxel incoherent motion (IVIM) technique in half-Fourier single-shot turbo spin-echo (HASTE) diffusion-weighted imaging (DWI), and to compare its accuracy to that of apparent diffusion coefficient (ADC) to predict malignancy in head and neck tumors. PATIENTS AND METHODS: HASTE DW images of 33 patients with head and neck tumors (10 benign and 23 malignant) were evaluated. Using the IVIM technique, parameters (D, true diffusion coefficient; f, perfusion fraction; D*, pseudodiffusion coefficient) were calculated for each tumor. ADC values were measured over a range of b values from 0 to 1000s/mm(2). IVIM parameters and ADC values in benign and malignant tumors were compared using Student's t test, receiver operating characteristics (ROC) analysis, and multivariate logistic regression modeling. RESULTS: Mean ADC and D values of malignant tumors were significantly lower than those of benign tumors (P<0.05). Mean D* values of malignant tumors were significantly higher than those of benign tumors (P<0.05). There was no significant difference in mean f values between malignant and benign tumors (P>0.05). The technique of combining D and D* was the best for predicting malignancy; accuracy for this model was higher than that for ADC. CONCLUSIONS: The IVIM technique may be applied in HASTE DWI as a diagnostic tool to predict malignancy in head and neck masses. The use of D and D* in combination increases the diagnostic accuracy in comparison with ADC.
PURPOSE: To evaluate the use of the intravoxel incoherent motion (IVIM) technique in half-Fourier single-shot turbo spin-echo (HASTE) diffusion-weighted imaging (DWI), and to compare its accuracy to that of apparent diffusion coefficient (ADC) to predict malignancy in head and neck tumors. PATIENTS AND METHODS: HASTE DW images of 33 patients with head and neck tumors (10 benign and 23 malignant) were evaluated. Using the IVIM technique, parameters (D, true diffusion coefficient; f, perfusion fraction; D*, pseudodiffusion coefficient) were calculated for each tumor. ADC values were measured over a range of b values from 0 to 1000s/mm(2). IVIM parameters and ADC values in benign and malignant tumors were compared using Student's t test, receiver operating characteristics (ROC) analysis, and multivariate logistic regression modeling. RESULTS: Mean ADC and D values of malignant tumors were significantly lower than those of benign tumors (P<0.05). Mean D* values of malignant tumors were significantly higher than those of benign tumors (P<0.05). There was no significant difference in mean f values between malignant and benign tumors (P>0.05). The technique of combining D and D* was the best for predicting malignancy; accuracy for this model was higher than that for ADC. CONCLUSIONS: The IVIM technique may be applied in HASTE DWI as a diagnostic tool to predict malignancy in head and neck masses. The use of D and D* in combination increases the diagnostic accuracy in comparison with ADC.
Authors: Qi-Yong Ai; Ann D King; Janet S M Chan; Weitian Chen; K C Allen Chan; John K S Woo; Benny C Y Zee; Anthony T C Chan; Darren M C Poon; Brigette B Y Ma; Edwin P Hui; Anil T Ahuja; Alexander C Vlantis; Jing Yuan Journal: Eur Radiol Date: 2019-03-22 Impact factor: 5.315
Authors: Yao Ding; John D Hazle; Abdallah S R Mohamed; Steven J Frank; Brian P Hobbs; Rivka R Colen; G Brandon Gunn; Jihong Wang; Jayashree Kalpathy-Cramer; Adam S Garden; Stephen Y Lai; David I Rosenthal; Clifton D Fuller Journal: NMR Biomed Date: 2015-10-09 Impact factor: 4.044
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