Neepa Patel1, John Hanfelt2, Laura Marsh3, Joseph Jankovic4. 1. Department of Neurology and Neurotherapeutics, Center for Movement Disorders, University of Texas Southwestern, Dallas, Texas, USA. 2. Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, USA. 3. Departments of Psychiatry and Neurology, Baylor College of Medicine, Houston, Texas, USA. 4. Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA.
Abstract
BACKGROUND: There is limited information on the phenomenology, clinical characteristics and pathophysiology of alleviating manoeuvres (AM), also called 'sensory tricks' in cervical dystonia (CD). METHODS: Individual data, collected from 10 sites participating in the Dystonia Coalition (http://clinicaltrials.gov/show/NCT01373424), included description of localisation and phenomenology of AM collected by systematic review of standardised video examinations. Analyses correlated demographic, neurologic, and psychiatric features of CD patients with or without effective AM. RESULTS: Of 154 people studied, 138 (89.6%) used AM, of which 60 (43.4%) reported partial improvement, 55 (39.8%) marked improvement, and 4 (0.03%) no effect on dystonic posture. Light touch, usually to the lower face or neck, was used by >90%. The presence or location of AM did not correlate with the severity of the dystonia. CONCLUSIONS: In this large and comprehensive study of CD, we found no clinical predictors of effective AM. Further studies of sensorimotor integration in dystonia are needed to better understand the pathophysiology of AM. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
BACKGROUND: There is limited information on the phenomenology, clinical characteristics and pathophysiology of alleviating manoeuvres (AM), also called 'sensory tricks' in cervical dystonia (CD). METHODS: Individual data, collected from 10 sites participating in the Dystonia Coalition (http://clinicaltrials.gov/show/NCT01373424), included description of localisation and phenomenology of AM collected by systematic review of standardised video examinations. Analyses correlated demographic, neurologic, and psychiatric features of CDpatients with or without effective AM. RESULTS: Of 154 people studied, 138 (89.6%) used AM, of which 60 (43.4%) reported partial improvement, 55 (39.8%) marked improvement, and 4 (0.03%) no effect on dystonic posture. Light touch, usually to the lower face or neck, was used by >90%. The presence or location of AM did not correlate with the severity of the dystonia. CONCLUSIONS: In this large and comprehensive study of CD, we found no clinical predictors of effective AM. Further studies of sensorimotor integration in dystonia are needed to better understand the pathophysiology of AM. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Authors: Ling Yan; Matt Hicks; Korey Winslow; Cynthia Comella; Christy Ludlow; H A Jinnah; Ami R Rosen; Laura Wright; Wendy R Galpern; Joel S Perlmutter Journal: Parkinsonism Relat Disord Date: 2015-01-20 Impact factor: 4.891
Authors: Scott A Norris; H A Jinnah; Alberto J Espay; Christine Klein; Norbert Brüggemann; Richard L Barbano; Irene Andonia C Malaty; Ramon L Rodriguez; Marie Vidailhet; Emmanuel Roze; Stephen G Reich; Brian D Berman; Mark S LeDoux; Sarah Pirio Richardson; Pinky Agarwal; Zoltan Mari; William G Ondo; Ludy C Shih; Susan H Fox; Alfredo Berardelli; Claudia M Testa; Florence Ching-Fen Cheng; Daniel Truong; Fatta B Nahab; Tao Xie; Mark Hallett; Ami R Rosen; Laura J Wright; Joel S Perlmutter Journal: Mov Disord Date: 2016-10-18 Impact factor: 10.338
Authors: Elizabeth Cisneros; Glenn T Stebbins; Qiyu Chen; Jeanne P Vu; Casey N Benadof; Zheng Zhang; Richard L Barbano; Susan H Fox; Christopher G Goetz; Joseph Jankovic; Hyder A Jinnah; Joel S Perlmutter; Charles H Adler; Stewart A Factor; Stephen G Reich; Ramon Rodriguez; Lawrence L Severt; Natividad P Stover; Brian D Berman; Cynthia L Comella; David A Peterson Journal: J Neurol Sci Date: 2020-11-01 Impact factor: 3.181
Authors: Elizabeth Cisneros; Jeanne P Vu; Ha Yeon Lee; Qiyu Chen; Casey N Benadof; Zheng Zhang; Emily A Pettitt; Subhagya K Joshi; Richard L Barbano; Joseph Jankovic; Hyder A Jinnah; Joel S Perlmutter; Brian D Berman; Abhimanyu Mahajan; Christopher G Goetz; Glenn T Stebbins; Cynthia L Comella; David A Peterson Journal: Tremor Other Hyperkinet Mov (N Y) Date: 2021-06-23