Literature DB >> 24827755

Atraumatic tooth extraction in patients taking bisphosphonates: a review of literature and experience with three cases.

Sebastian Hoefert1, Martin Grimm, Feraydoon Sharghi, Andreas Geist, Michael Krimmel, Siegmar Reinert.   

Abstract

PURPOSE: Regev et al. first re-introduced the method of atraumatic tooth extraction with orthodontic elastics in 2008. Since then, the method has been mentioned regularly in literature. Nevertheless, the need for additional more detailed information remains.
METHODS: We present a review of literature and a retrospective analysis of our three patients receiving bisphosphonate medication. Two of our patients suffered from bisphosphonate-related osteonecrosis of the jaw (BRONJ). All three patients underwent atraumatic tooth extraction, which we describe in detail.
RESULTS: Regev et al. reported satisfactory results using the novel method. We removed six teeth in two patients with continued chemotherapy or bisphosphonate therapy in a time span of 26.2 ± 16.4 weeks successfully. None of the patients developed exposed bone in the follow-up (7.4 ± 0.2 months). In one case, the technique had to be discontinued due to increasing tooth soreness.
CONCLUSIONS: Atraumatic tooth extraction seems to be a safe method to prevent bone exposure, even in cases with BRONJ. The time required of our patients for exfoliation exceeded the time mentioned in literature considerably. This proved to be a major limitation. Our cases showed that patients with good compliance, no sore teeth, or painful BRONJ lesions, benefited from atraumatic tooth extraction. One of the method's major advantages might be the possibility to continue chemotherapy and bisphosphonate therapy throughout the treatment.

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Year:  2014        PMID: 24827755     DOI: 10.1007/s10006-014-0452-7

Source DB:  PubMed          Journal:  Oral Maxillofac Surg        ISSN: 1865-1550


  43 in total

Review 1.  Emerging approaches for prophylaxis and management of oropharyngeal mucositis in cancer therapy.

Authors:  Joel B Epstein; Gary D Klasser
Journal:  Expert Opin Emerg Drugs       Date:  2006-05       Impact factor: 4.191

Review 2.  Jaw osteonecrosis associated with bisphosphonates: multiple exposed areas and its relationship to teeth extractions. Study of 20 cases.

Authors:  Jose V Bagan; Yolanda Jimenez; Judith Murillo; Sergio Hernandez; Rafael Poveda; José M Sanchis; José M Diaz; Crispian Scully
Journal:  Oral Oncol       Date:  2005-11-04       Impact factor: 5.337

3.  Relationship between intake of green tea and periodontal disease.

Authors:  Mitoshi Kushiyama; Yoshihiro Shimazaki; Masatoshi Murakami; Yoshihisa Yamashita
Journal:  J Periodontol       Date:  2009-03       Impact factor: 6.993

4.  Novel therapy to reverse the cellular effects of bisphosphonates on primary human oral fibroblasts.

Authors:  Matthew Cozin; Bradley M Pinker; Kimberley Solemani; Jeremy M Zuniga; Stephen C Dadaian; Serge Cremers; Regina Landesberg; Srikala Raghavan
Journal:  J Oral Maxillofac Surg       Date:  2011-07-31       Impact factor: 1.895

5.  Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice.

Authors:  Yasuyoshi Kobayashi; Toru Hiraga; Akimi Ueda; Liyang Wang; Michiyo Matsumoto-Nakano; Kenji Hata; Hirofumi Yatani; Toshiyuki Yoneda
Journal:  J Bone Miner Metab       Date:  2009-10-31       Impact factor: 2.626

6.  Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia.

Authors:  Tony Mavrokokki; Andrew Cheng; Brien Stein; Alastair Goss
Journal:  J Oral Maxillofac Surg       Date:  2007-03       Impact factor: 1.895

7.  Occurrence of bisphosphonate-related osteonecrosis of the jaw after surgical tooth extraction.

Authors:  Giorgia Saia; Stella Blandamura; Giordana Bettini; Anita Tronchet; Andrea Totola; Giorgio Bedogni; Giuseppe Ferronato; Pier Francesco Nocini; Alberto Bedogni
Journal:  J Oral Maxillofac Surg       Date:  2010-04       Impact factor: 1.895

Review 8.  A review of the clinical implications of bisphosphonates in dentistry.

Authors:  G L Borromeo; C E Tsao; I B Darby; P R Ebeling
Journal:  Aust Dent J       Date:  2010-12-22       Impact factor: 2.291

9.  Nationwide survey for bisphosphonate-related osteonecrosis of the jaws in Japan.

Authors:  Masahiro Urade; Noriaki Tanaka; Kiyofumi Furusawa; Jun Shimada; Takanori Shibata; Tadaaki Kirita; Tetsuya Yamamoto; Tetsuro Ikebe; Yoshimasa Kitagawa; Jinichi Fukuta
Journal:  J Oral Maxillofac Surg       Date:  2011-07-23       Impact factor: 1.895

Review 10.  A review of bisphosphonate-associated osteonecrosis of the jaws and its management.

Authors:  David K Lam; George K B Sándor; Howard I Holmes; A Wayne Evans; Cameron M L Clokie
Journal:  J Can Dent Assoc       Date:  2007-06       Impact factor: 1.316

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  2 in total

Review 1.  The risk of osteonecrosis of the jaw and adverse outcomes in patients using antiresorptive drugs undergoing orthodontic treatment: A systematic review.

Authors:  Julian Woolley; Oladapo Akintola; Julian Yates; Monica Diuana Calasans-Maia; Jose de Albuquerque Calasans-Maia; Iryna Kocherhina; Roberto Sacco
Journal:  Heliyon       Date:  2021-01-13

Review 2.  Prevention of medication-related osteonecrosis of the jaws secondary to tooth extractions. A systematic review.

Authors:  Márcio Diniz-Freitas; Jacobo Limeres
Journal:  Med Oral Patol Oral Cir Bucal       Date:  2016-03-01
  2 in total

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