| Literature DB >> 17555652 |
David K Lam1, George K B Sándor, Howard I Holmes, A Wayne Evans, Cameron M L Clokie.
Abstract
Bisphosphonate-associated osteonecrosis (BON) may result in serious oral complications, such as osteomyelitis and chronic exposure of necrotic bone. Dentists must be familiar with this disorder and pay special attention to all patients on bisphosphonate therapy due to their defective osteoclast function and reduced osseous tissue vascularity, leading to impaired wound healing. The purpose of this paper is to review the history and pathogenesis of BON, discuss its differential diagnosis, provide guidance to dentists on possible measures to prevent BON and review the management of patients with BON.Entities:
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Year: 2007 PMID: 17555652
Source DB: PubMed Journal: J Can Dent Assoc ISSN: 0709-8936 Impact factor: 1.316