AIMS: To examine the association between diabetes duration and hypoglycaemia symptom profiles and the presence of impaired awareness of hypoglycaemia. METHODS: A cross-sectional study was performed, using validated methods for recording hypoglycaemia symptoms and assessing hypoglycaemia awareness. The associations between symptom intensity, hypoglycaemia awareness and diabetes duration were examined, and the prevalence of impaired awareness was ascertained for Type 1 diabetes of differing durations. RESULTS: Questionnaires were mailed to 636 adults with Type 1 diabetes, of whom 445 (70%) returned them. A total of 440 completed questionnaires were suitable for analysis. Longer diabetes duration was associated with lower intensity of autonomic symptoms (P for trend <0.001), but no association was observed with neuroglycopenic symptoms. The overall prevalence of impaired awareness of hypoglycaemia in this cohort was 17% (95% CI 14-21%) and increased with diabetes duration, from 3% for duration 2-9 years to 28% for duration ≥30 years (P for trend <0.001). Low autonomic symptom scores were not associated with a higher prevalence of impaired awareness. CONCLUSIONS: Longer diabetes duration was associated with lower intensity of autonomic symptoms and a higher prevalence of impaired awareness of hypoglycaemia, suggesting that subjective symptoms of hypoglycaemia change over time. These observations underline the need for regular patient education about hypoglycaemia symptomatology and clinical screening for impaired awareness of hypoglycaemia.
AIMS: To examine the association between diabetes duration and hypoglycaemia symptom profiles and the presence of impaired awareness of hypoglycaemia. METHODS: A cross-sectional study was performed, using validated methods for recording hypoglycaemia symptoms and assessing hypoglycaemia awareness. The associations between symptom intensity, hypoglycaemia awareness and diabetes duration were examined, and the prevalence of impaired awareness was ascertained for Type 1 diabetes of differing durations. RESULTS: Questionnaires were mailed to 636 adults with Type 1 diabetes, of whom 445 (70%) returned them. A total of 440 completed questionnaires were suitable for analysis. Longer diabetes duration was associated with lower intensity of autonomic symptoms (P for trend <0.001), but no association was observed with neuroglycopenic symptoms. The overall prevalence of impaired awareness of hypoglycaemia in this cohort was 17% (95% CI 14-21%) and increased with diabetes duration, from 3% for duration 2-9 years to 28% for duration ≥30 years (P for trend <0.001). Low autonomic symptom scores were not associated with a higher prevalence of impaired awareness. CONCLUSIONS: Longer diabetes duration was associated with lower intensity of autonomic symptoms and a higher prevalence of impaired awareness of hypoglycaemia, suggesting that subjective symptoms of hypoglycaemia change over time. These observations underline the need for regular patient education about hypoglycaemia symptomatology and clinical screening for impaired awareness of hypoglycaemia.
Authors: Anne-Sophie Sejling; Kai H W Lange; Christian S Frandsen; Sarah S Diemar; Lise Tarnow; Jens Faber; Jens J Holst; Bolette Hartmann; Linda Hilsted; Troels W Kjaer; Claus B Juhl; Birger Thorsteinsson; Ulrik Pedersen-Bjergaard Journal: Diabetologia Date: 2015-05-19 Impact factor: 10.122
Authors: Jayne Smith-Palmer; Jay P Bae; Kristina S Boye; Kirsi Norrbacka; Barnaby Hunt; William J Valentine Journal: Clinicoecon Outcomes Res Date: 2016-10-07
Authors: Tor I Hansen; Sandra E Olsen; Elise C D Haferstrom; Trond Sand; Brian M Frier; Asta K Håberg; Marit R Bjørgaas Journal: Diabetologia Date: 2017-03-09 Impact factor: 10.122
Authors: Lian A van Meijel; Femmie de Vegt; Evertine J Abbink; Femke Rutters; Miranda T Schram; Melanie M van der Klauw; Bruce H R Wolffenbuttel; Sarah Siegelaar; J Hans DeVries; Eric J G Sijbrands; Behiye Özcan; Harold W de Valk; Bianca Silvius; Nicolaas Schaper; Coen D A Stehouwer; Petra J M Elders; Cornelis J Tack; Bastiaan E de Galan Journal: BMJ Open Diabetes Res Care Date: 2020-02