Literature DB >> 24823636

Endoplasmic reticulum stress in malignancy.

Hanna J Clarke1, Joseph E Chambers1, Elizabeth Liniker1, Stefan J Marciniak2.   

Abstract

The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival. In this review, we examine the evidence implicating endoplasmic reticulum dysfunction in the pathology of cancer and discuss how recent findings may help to identify novel therapeutic targets.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 24823636     DOI： 10.1016/j.ccr.2014.03.015

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  177 in total

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2.  The novel autophagy inhibitor elaiophylin exerts antitumor activity against multiple myeloma with mutant TP53 in part through endoplasmic reticulum stress-induced apoptosis.

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5.  C. sakazakii activates AIM2 pathway accompanying with excessive ER stress response in mammalian mammary gland epithelium.

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Review 7.  Molecular mechanisms of the preventable causes of cancer in the United States.

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8.  Codon misreading tRNAs promote tumor growth in mice.

Authors:  Mafalda Santos; Patricia M Pereira; A Sofia Varanda; Joana Carvalho; Mafalda Azevedo; Denisa D Mateus; Nuno Mendes; Patricia Oliveira; Fábio Trindade; Marta Teixeira Pinto; Renata Bordeira-Carriço; Fátima Carneiro; Rui Vitorino; Carla Oliveira; Manuel A S Santos
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