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Literature DB >> 2482302

Immunoreactive determinants of CA 125 in women with endometriosis.

O A Mojiminiyi¹, M E Bramwell, S H Kennedy, B J Shepstone, S M Humm, D H Barlow.

Abstract

Among 10 patients with endometriosis CA 125 was increased (greater than 35 U/ml) in endometriotic cyst fluid in all the patients, but only two had increased serum concentrations. Gel electrophoresis of serum, endometriotic cyst fluid, and endometriotic tissue resolved the CA 125 immunoreactive fragments from the three sources into bands of similar electrophoretic mobilities. Electrophoresis under reducing and non-reducing conditions showed immunoreactive fragments of apparent masses of 55,000 and 140,000 daltons, respectively. Analysis under reducing conditions did not result in loss of activity. CA 125 antigen is thought to be a high molecular weight glycoprotein complex. As far as is known, this is the first report describing lower molecular weight immunoreactive determinants of CA 125.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2482302 PMCID： PMC502054 DOI： 10.1136/jcp.42.12.1272

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

20 in total

1. The tumor marker CA 125 is a common constituent of normal cervical mucus.

Authors: H W de Bruijn; T van Beeck Calkoen-Carpay; S Jager; J M Duk; J G Aalders; G J Fleuren
Journal: Am J Obstet Gynecol Date: 1986-05 Impact factor: 8.661

2. CA-125 levels in endometriosis.

Authors: P E Patton; C S Field; R W Harms; C B Coulam
Journal: Fertil Steril Date: 1986-06 Impact factor: 7.329

3. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

4. Immunohistochemical localization of CA 125 antigen in formalin-fixed paraffin sections of ovarian tumors with the use of Pronase.

Authors: J Shishi; M Ghazizadeh; T Oguro; K Aihara; T Araki
Journal: Am J Clin Pathol Date: 1986-05 Impact factor: 2.493

5. Immunohistochemical localization of placental alkaline phosphatase, carcinoembryonic antigen, and cancer antigen 125 in normal and neoplastic human lung.

Authors: E J Nouwen; D E Pollet; M W Eerdekens; P G Hendrix; T W Briers; M E De Broe
Journal: Cancer Res Date: 1986-02 Impact factor: 12.701

1. Distribution of radiolabelled anti-CA125 monoclonal antibody OC125-F(ab)2-fragment following resection guided by antibodies (REGAJ) in ovarian cancer patients.

Authors: M M Uttenreuther-Fischer; H Feistel; F Wolf; W Jäger
Journal: J Clin Lab Anal Date: 1997 Impact factor: 2.352

1 in total

Immunoreactive determinants of CA 125 in women with endometriosis.

1. The tumor marker CA 125 is a common constituent of normal cervical mucus.

2. CA-125 levels in endometriosis.

3. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

4. Immunohistochemical localization of CA 125 antigen in formalin-fixed paraffin sections of ovarian tumors with the use of Pronase.

5. Immunohistochemical localization of placental alkaline phosphatase, carcinoembryonic antigen, and cancer antigen 125 in normal and neoplastic human lung.

6. Immunoscintigraphy of ovarian endometriosis. A preliminary study.

7. Ca 125 and Ca 19-9: two cancer-associated sialylsaccharide antigens on a mucus glycoprotein from human milk.

8. Reactivity of a monoclonal antibody with human ovarian carcinoma.

9. Interaction of monoclonal antibodies with cell surface antigens of human ovarian carcinomas.

10. Detection of ovarian cancer marker CA 125 in human seminal plasma.

1. Distribution of radiolabelled anti-CA125 monoclonal antibody OC125-F(ab)2-fragment following resection guided by antibodies (REGAJ) in ovarian cancer patients.