C Ballegaard1, R G C Riis2, H Bliddal3, R Christensen4, M Henriksen5, E M Bartels6, L S Lohmander7, D J Hunter8, R Bouert9, M Boesen10. 1. The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg-Frederiksberg, Copenhagen F, Denmark. Electronic address: christine_ballegaard@hotmail.com. 2. The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg-Frederiksberg, Copenhagen F, Denmark; Department of Radiology, Copenhagen University Hospital, Bispebjerg-Frederiksberg, Copenhagen F, Denmark. Electronic address: robert.gabriel.riis@regionh.dk. 3. The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg-Frederiksberg, Copenhagen F, Denmark. Electronic address: henning.bliddal@frh.regionh.dk. 4. The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg-Frederiksberg, Copenhagen F, Denmark; Institute of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. Electronic address: robin.christensen@frh.regionh.dk. 5. The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg-Frederiksberg, Copenhagen F, Denmark. Electronic address: marius.henriksen@regionh.dk. 6. The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg-Frederiksberg, Copenhagen F, Denmark. Electronic address: else.marie.bartels@regionh.dk. 7. Institute of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark; Department of Orthopaedics, Clinical Sciences Lund, Lund University, Sweden; Department of Orthopaedics and Traumatology, University of Southern Denmark, Odense, Denmark. Electronic address: stefan.lohmander@med.lu.se. 8. Rheumatology Department, Royal North Shore Hospital and Kolling Institute, University of Sydney, NSW, Australia. Electronic address: david.hunter@sydney.edu.au. 9. Department of Radiology, Copenhagen University Hospital, Bispebjerg-Frederiksberg, Copenhagen F, Denmark. Electronic address: rasmus.bouert@regionh.dk. 10. The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg-Frederiksberg, Copenhagen F, Denmark; Department of Radiology, Copenhagen University Hospital, Bispebjerg-Frederiksberg, Copenhagen F, Denmark. Electronic address: mikael.boesen@gmail.com.
Abstract
OBJECTIVE: To investigate the association between knee pain and signs of inflammation in the infrapatellar fat pad (IPFP) in obese patients with knee osteoarthritis (KOA). DESIGN: In a cross-sectional setting, 3-T conventional contrast-enhanced (CE) magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE)-MRI of KOA were analysed to quantify the extent of inflammation in the IPFP, and correlated (Spearman's rank correlation) to pain and other symptoms assessed via the Knee injury and Osteoarthritis Outcome Score (KOOS) (100 = no pain, 0 = extreme pain). The extent of inflammation in the IPFP was assessed according to the MRI Osteoarthritis Knee Score (MOAKS) using CE-MRI and by DCE-MRI perfusion variables. The perfusion variable, "Inflammation", was chosen as primary perfusion variable in the analysis. Intraclass correlation coefficients for the perfusion variables ranged from 0.81 to 0.99. RESULTS: MRI and clinical data were obtained in 95 patients. The typical patient was a woman (82%) with an average age of 65 years (SD 6.5) and a body mass index (BMI) of 32 kg/m(2) (SD 3.7). The bivariate association between KOOS pain and the DCE-MRI perfusion variable "Inflammation" showed a statistically significant correlation (r = -0.42, P < 0.0001). A statistically significant correlation was also found between KOOS pain and MOAKS Hoffa-synovitis (r = -0.21, P = 0.046). CONCLUSIONS: Perfusion variables on DCE-MRI reflecting the severity of inflammation in the IPFP and MOAKS Hoffa-synovitis were associated with the severity of pain in KOA. These results suggest that severe inflammation in the IPFP is associated with severe pain in KOA and that DCE-MRI is a promising method to study the impact of inflammation in KOA.
OBJECTIVE: To investigate the association between knee pain and signs of inflammation in the infrapatellar fat pad (IPFP) in obesepatients with knee osteoarthritis (KOA). DESIGN: In a cross-sectional setting, 3-T conventional contrast-enhanced (CE) magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE)-MRI of KOA were analysed to quantify the extent of inflammation in the IPFP, and correlated (Spearman's rank correlation) to pain and other symptoms assessed via the Knee injury and Osteoarthritis Outcome Score (KOOS) (100 = no pain, 0 = extreme pain). The extent of inflammation in the IPFP was assessed according to the MRI Osteoarthritis Knee Score (MOAKS) using CE-MRI and by DCE-MRI perfusion variables. The perfusion variable, "Inflammation", was chosen as primary perfusion variable in the analysis. Intraclass correlation coefficients for the perfusion variables ranged from 0.81 to 0.99. RESULTS: MRI and clinical data were obtained in 95 patients. The typical patient was a woman (82%) with an average age of 65 years (SD 6.5) and a body mass index (BMI) of 32 kg/m(2) (SD 3.7). The bivariate association between KOOS pain and the DCE-MRI perfusion variable "Inflammation" showed a statistically significant correlation (r = -0.42, P < 0.0001). A statistically significant correlation was also found between KOOS pain and MOAKS Hoffa-synovitis (r = -0.21, P = 0.046). CONCLUSIONS: Perfusion variables on DCE-MRI reflecting the severity of inflammation in the IPFP and MOAKS Hoffa-synovitis were associated with the severity of pain in KOA. These results suggest that severe inflammation in the IPFP is associated with severe pain in KOA and that DCE-MRI is a promising method to study the impact of inflammation in KOA.
Authors: Nathan M Solbak; Bryan J Heard; Yamini Achari; May Chung; Nigel G Shrive; Cyril B Frank; David A Hart Journal: Inflamm Res Date: 2015-06-20 Impact factor: 4.575
Authors: A Ruhdorfer; F Haniel; T Petersohn; J Dörrenberg; W Wirth; T Dannhauer; D J Hunter; F Eckstein Journal: Osteoarthritis Cartilage Date: 2017-02-12 Impact factor: 6.576
Authors: A K Carlson; R A Rawle; C W Wallace; E G Brooks; E Adams; M C Greenwood; M Olmer; M K Lotz; B Bothner; R K June Journal: Osteoarthritis Cartilage Date: 2019-04-25 Impact factor: 6.576
Authors: Kang Wang; Changhai Ding; Michael J Hannon; Zhongshan Chen; C Kent Kwoh; David J Hunter Journal: Arthritis Care Res (Hoboken) Date: 2019-01 Impact factor: 4.794
Authors: Cecilie L Daugaard; Robert Gc Riis; Elisabeth Bandak; Henrik Gudbergsen; Marius Henriksen; Henning Bliddal; Mikael Boesen Journal: Skeletal Radiol Date: 2019-12-09 Impact factor: 2.199