Literature DB >> 24820072

Phase-variable expression of lptA modulates the resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides.

Justin L Kandler1, Sandeep J Joseph2, Jacqueline T Balthazar1, Vijaya Dhulipala1, Timothy D Read2, Ann E Jerse3, William M Shafer4.   

Abstract

Phosphoethanolamine (PEA) decoration of lipid A produced by Neisseria gonorrhoeae has been linked to bacterial resistance to cationic antimicrobial peptides/proteins (CAMPs) and in vivo fitness during experimental infection. We now report that the lptA gene, which encodes the PEA transferase responsible for this decoration, is in an operon and that high-frequency mutation in a polynucleotide repeat within lptA can influence gonococcal resistance to CAMPs.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24820072      PMCID： PMC4068544          DOI： 10.1128/AAC.03108-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Cationic antimicrobial peptide resistance in Neisseria meningitidis.

Authors:  Yih-Ling Tzeng; Karita D Ambrose; Susu Zughaier; Xiaoliu Zhou; Yoon K Miller; William M Shafer; David S Stephens
Journal:  J Bacteriol       Date:  2005-08       Impact factor: 3.490

2.  Identification of the gene (lgtG) encoding the lipooligosaccharide beta chain synthesizing glucosyl transferase from Neisseria gonorrhoeae.

Authors:  A Banerjee; R Wang; S N Uljon; P A Rice; E C Gotschlich; D C Stein
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

3.  Comparative whole-genome analyses reveal over 100 putative phase-variable genes in the pathogenic Neisseria spp.

Authors:  Lori A S Snyder; Sarah A Butcher; Nigel J Saunders
Journal:  Microbiology       Date:  2001-08       Impact factor: 2.777

4.  Phosphoethanolamine residues on the lipid A moiety of Neisseria gonorrhoeae lipooligosaccharide modulate binding of complement inhibitors and resistance to complement killing.

Authors:  Lisa A Lewis; William M Shafer; Tathagat Dutta Ray; Sanjay Ram; Peter A Rice
Journal:  Infect Immun       Date:  2012-10-15       Impact factor: 3.441

5.  The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin.

Authors:  Christopher Wanty; Anandhi Anandan; Susannah Piek; James Walshe; Jhuma Ganguly; Russell W Carlson; Keith A Stubbs; Charlene M Kahler; Alice Vrielink
Journal:  J Mol Biol       Date:  2013-06-28       Impact factor: 5.469

6.  Phosphoethanolamine substitution of lipid A and resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides and complement-mediated killing by normal human serum.

Authors:  Lisa A Lewis; Biswa Choudhury; Jacqueline T Balthazar; Larry E Martin; Sanjay Ram; Peter A Rice; David S Stephens; Russell Carlson; William M Shafer
Journal:  Infect Immun       Date:  2008-12-29       Impact factor: 3.441

7.  In vitro resistance mechanisms of Neisseria meningitidis against neutrophil extracellular traps.

Authors:  Martin Lappann; Sophia Danhof; Frank Guenther; Silvana Olivares-Florez; Ines Louise Mordhorst; Ulrich Vogel
Journal:  Mol Microbiol       Date:  2013-06-25       Impact factor: 3.501

8.  Lack of lipid A pyrophosphorylation and functional lptA reduces inflammation by Neisseria commensals.

Authors:  Constance M John; Mingfeng Liu; Nancy J Phillips; Zhijie Yang; Courtney R Funk; Lindsey I Zimmerman; J McLeod Griffiss; Daniel C Stein; Gary A Jarvis
Journal:  Infect Immun       Date:  2012-09-04       Impact factor: 3.441

9.  A novel mechanism of high-level, broad-spectrum antibiotic resistance caused by a single base pair change in Neisseria gonorrhoeae.

Authors:  Elizabeth A Ohneck; Yaramah M Zalucki; Paul J T Johnson; Vijaya Dhulipala; Daniel Golparian; Magnus Unemo; Ann E Jerse; William M Shafer
Journal:  mBio       Date:  2011-09-20       Impact factor: 7.867

10.  Variation of gonococcal lipooligosaccharide structure is due to alterations in poly-G tracts in lgt genes encoding glycosyl transferases.

Authors:  Q L Yang; E C Gotschlich
Journal:  J Exp Med       Date:  1996-01-01       Impact factor: 14.307
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  13 in total

Review 1.  Antimicrobial peptide resistance in Neisseria meningitidis.

Authors:  Yih-Ling Tzeng; David S Stephens
Journal:  Biochim Biophys Acta       Date:  2015-05-19

Review 2.  Gonococcal Defenses against Antimicrobial Activities of Neutrophils.

Authors:  Allison Palmer; Alison K Criss
Journal:  Trends Microbiol       Date:  2018-08-13       Impact factor: 17.079

3.  The lipooligosaccharide-modifying enzyme LptA enhances gonococcal defence against human neutrophils.

Authors:  Jonathan W Handing; Alison K Criss
Journal:  Cell Microbiol       Date:  2015-02-04       Impact factor: 3.715

4.  Predominant phosphorylation patterns in Neisseria meningitidis lipid A determined by top-down MS/MS.

Authors:  Constance M John; Nancy J Phillips; Gary A Jarvis
Journal:  J Lipid Res       Date:  2020-08-24       Impact factor: 5.922

5.  Efficacy of Antigonococcal CMP-Nonulosonate Therapeutics Require Cathelicidins.

Authors:  Sunita Gulati; Ian C Schoenhofen; Theresa Lindhout-Djukic; Lisa A Lewis; Iesha Y Moustafa; Sudeshna Saha; Bo Zheng; Nancy Nowak; Peter A Rice; Ajit Varki; Sanjay Ram
Journal:  J Infect Dis       Date:  2020-10-13       Impact factor: 5.226

Review 6.  Pathogenesis of Neisseria gonorrhoeae in the female reproductive tract: neutrophilic host response, sustained infection, and clinical sequelae.

Authors:  Jacqueline S Stevens; Alison K Criss
Journal:  Curr Opin Hematol       Date:  2018-01       Impact factor: 3.284

7.  The MisR Response Regulator Is Necessary for Intrinsic Cationic Antimicrobial Peptide and Aminoglycoside Resistance in Neisseria gonorrhoeae.

Authors:  Justin L Kandler; Concerta L Holley; Jennifer L Reimche; Vijaya Dhulipala; Jacqueline T Balthazar; Artur Muszyński; Russell W Carlson; William M Shafer
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191

Review 8.  Antimicrobial peptides in 2014.

Authors:  Guangshun Wang; Biswajit Mishra; Kyle Lau; Tamara Lushnikova; Radha Golla; Xiuqing Wang
Journal:  Pharmaceuticals (Basel)       Date:  2015-03-23

9.  Mathematical and live meningococcal models for simple sequence repeat dynamics - coherent predictions and observations.

Authors:  Kristian Alfsnes; Xavier Raynaud; Tone Tønjum; Ole Herman Ambur
Journal:  PLoS One       Date:  2014-07-07       Impact factor: 3.240

10.  Phosphoethanolamine Modification of Neisseria gonorrhoeae Lipid A Reduces Autophagy Flux in Macrophages.

Authors:  Susu M Zughaier; Justin L Kandler; Jacqueline T Balthazar; William M Shafer
Journal:  PLoS One       Date:  2015-12-07       Impact factor: 3.240
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