Henrique Nascimento1, Elísio Costa1, Susana Rocha1, Clarice Lucena2, Petronila Rocha-Pereira3, Carla Rêgo4, Helena Ferreira Mansilha5, Alexandre Quintanilha6, Luísa Aires2, Jorge Mota7, Alice Santos-Silva1, Luís Belo1. 1. 1] Biological Science Department, Faculty of Pharmacy, University of Oporto, Oporto, Portugal [2] Institute for Molecular and Cell Biology, University of Oporto, Oporto, Portugal. 2. 1] Research Centre in Physical Activity, Health and Leisure - CIAFEL, Faculty of Sports, University of Oporto, Oporto, Portugal [2] High Education Institute From Maia - ISMAI, Maia, Portugal. 3. Health Science Research Centre, University of Beira Interior, Covilhã, Portugal. 4. Children and Adolescent Centre, CUF Hospital, Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine, University of Oporto, Oporto, Portugal. 5. Childhood and Adolescence Department, Paediatric Service, Oporto Hospital Centre, Oporto, Portugal. 6. 1] Institute for Molecular and Cell Biology, University of Oporto, Oporto, Portugal [2] Abel Salazar Biomedical Sciences Institute, University of Oporto, Oporto, Portugal. 7. Research Centre in Physical Activity, Health and Leisure - CIAFEL, Faculty of Sports, University of Oporto, Oporto, Portugal.
Abstract
BACKGROUND: Adiponectin circulates as low-, medium-, and high-molecular-weight multimers (LMW, MMW, and HMW) and influences lipid profile and insulin resistance (IR), HMW being considered as the most biologically active form. We aimed to study the relation between adiponectin and markers of metabolic syndrome (MS) in pediatric obesity, and the impact of physical exercise. METHODS: The study consisted of a cross-sectional part and an 8-mo physical exercise program. Lipid profile, insulin, glucose, C-reactive protein (CRP), total adiponectin (TA), and homeostasis model assessment IR (HOMA-IR) were measured. Adiponectin multimers were studied in a prepubertal group. RESULTS: Obesity is associated with increased dyslipidemia, IR, and inflammation. TA is correlated inversely with adiposity, triglycerides, HOMA-IR, and CRP, and positively with high-density lipoprotein cholesterol (HDLc)/total cholesterol (TC) ratio. HMW mimicked TA associations. The intervention program led to a reduction of TC, low-density lipoprotein cholesterol (LDLc), insulin, HOMA-IR, and trunk percentage of fat, and an increase of HDLc/TC ratio, in the obese group. BMI improvements prevented adiponectin reduction and correlated with increments in HMW and MMW. CONCLUSION: Obesity-related increase in MS features might be linked to lower adiponectin. HMW and MMW were the multimers that most explained the MS features. The intervention program improved the lipid profile and IR, and prevented the reduction of adiponectin.
BACKGROUND:Adiponectin circulates as low-, medium-, and high-molecular-weight multimers (LMW, MMW, and HMW) and influences lipid profile and insulin resistance (IR), HMW being considered as the most biologically active form. We aimed to study the relation between adiponectin and markers of metabolic syndrome (MS) in pediatric obesity, and the impact of physical exercise. METHODS: The study consisted of a cross-sectional part and an 8-mo physical exercise program. Lipid profile, insulin, glucose, C-reactive protein (CRP), total adiponectin (TA), and homeostasis model assessment IR (HOMA-IR) were measured. Adiponectin multimers were studied in a prepubertal group. RESULTS: Obesity is associated with increased dyslipidemia, IR, and inflammation. TA is correlated inversely with adiposity, triglycerides, HOMA-IR, and CRP, and positively with high-density lipoprotein cholesterol (HDLc)/total cholesterol (TC) ratio. HMW mimicked TA associations. The intervention program led to a reduction of TC, low-density lipoprotein cholesterol (LDLc), insulin, HOMA-IR, and trunk percentage of fat, and an increase of HDLc/TC ratio, in the obese group. BMI improvements prevented adiponectin reduction and correlated with increments in HMW and MMW. CONCLUSION: Obesity-related increase in MS features might be linked to lower adiponectin. HMW and MMW were the multimers that most explained the MS features. The intervention program improved the lipid profile and IR, and prevented the reduction of adiponectin.
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Authors: Rashmi Supriya; Bjorn T Tam; Angus P Yu; Paul H Lee; Christopher W Lai; Kenneth K Cheng; Sonata Y Yau; Lawrence W Chan; Benjamin Y Yung; Sinead Sheridan; Parco M Siu Journal: PLoS One Date: 2018-08-16 Impact factor: 3.240
Authors: Javier A. Magaña Gomez; Daniela Moreno-Mascareño; Carla E. Angulo Rojo; Gisela Duarte de la Peña Journal: J Clin Res Pediatr Endocrinol Date: 2019-09-25