PURPOSE: Previous studies have revealed that an elevated preoperative serum C-reactive protein (CRP) level is associated with a poor prognosis in patients with various malignant tumors. The aim of this study was to determine the clinical significance of the preoperative serum CRP level in patients with stage IV colorectal cancer. METHODS: We enrolled 144 patients who underwent surgery for stage IV colorectal cancer. A total of 53 patients with a serum CRP level of ≥ 1.0 mg/dl were classified as the high CRP individuals. The association between the preoperative serum CRP level and survival was retrospectively assessed. RESULTS: The cancer-specific survival of the patients with a high CRP level was significantly worse than that of the patients with a low CRP level. A multivariate analysis indicated that the curability (non-curative surgery), the number of organs with metastasis (more than one organ), the tumor diameter (≥ 5 cm), lymphatic involvement, histological differentiation (non-differentiated) and a high CRP level (≥ 1.0 mg/dl) were independent risk factors for a poor survival. CONCLUSIONS: A high preoperative serum CRP level is a convenient biomarker for identifying patients with a poor prognosis for stage IV colorectal cancer.
PURPOSE: Previous studies have revealed that an elevated preoperative serum C-reactive protein (CRP) level is associated with a poor prognosis in patients with various malignant tumors. The aim of this study was to determine the clinical significance of the preoperative serum CRP level in patients with stage IV colorectal cancer. METHODS: We enrolled 144 patients who underwent surgery for stage IV colorectal cancer. A total of 53 patients with a serum CRP level of ≥ 1.0 mg/dl were classified as the high CRP individuals. The association between the preoperative serum CRP level and survival was retrospectively assessed. RESULTS: The cancer-specific survival of the patients with a high CRP level was significantly worse than that of the patients with a low CRP level. A multivariate analysis indicated that the curability (non-curative surgery), the number of organs with metastasis (more than one organ), the tumor diameter (≥ 5 cm), lymphatic involvement, histological differentiation (non-differentiated) and a high CRP level (≥ 1.0 mg/dl) were independent risk factors for a poor survival. CONCLUSIONS: A high preoperative serum CRP level is a convenient biomarker for identifying patients with a poor prognosis for stage IV colorectal cancer.
Authors: Nikolaos I Nikiteas; Nikolaos Tzanakis; Maria Gazouli; George Rallis; Kessaris Daniilidis; George Theodoropoulos; Alkiviadis Kostakis; George Peros Journal: World J Gastroenterol Date: 2005-03-21 Impact factor: 5.742
Authors: M Oka; K Yamamoto; M Takahashi; M Hakozaki; T Abe; N Iizuka; S Hazama; K Hirazawa; H Hayashi; A Tangoku; K Hirose; T Ishihara; T Suzuki Journal: Cancer Res Date: 1996-06-15 Impact factor: 12.701
Authors: Alessandro Passardi; Emanuela Scarpi; Luigi Cavanna; Monia Dall'Agata; Davide Tassinari; Silvana Leo; Ilaria Bernardini; Fabio Gelsomino; Stefano Tamberi; Alba A Brandes; Elena Tenti; Roberto Vespignani; Giovanni L Frassineti; Dino Amadori; Ugo De Giorgi Journal: Oncotarget Date: 2016-05-31