Gaëlle Coureau1, Ghislaine Bouvier2, Pierre Lebailly3, Pascale Fabbro-Peray4, Anne Gruber5, Karen Leffondre6, Jean-Sebastien Guillamo7, Hugues Loiseau8, Simone Mathoulin-Pélissier6, Roger Salamon9, Isabelle Baldi10. 1. Laboratoire Santé Travail Environnement, Univ. Bordeaux, ISPED, Bordeaux, France INSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, Bordeaux, France CHU de Bordeaux, Service d'information médicale, Bordeaux, France. 2. Laboratoire Santé Travail Environnement, Univ. Bordeaux, ISPED, Bordeaux, France INSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, Bordeaux, France. 3. INSERM, UMR1086-Cancers et Préventions, Caen, France Univ. Caen Basse-Normandie, Caen, France Centre François Baclesse, Caen, France. 4. Laboratoire d'Epidémiologie et de Biostatistiques, Univ. Montpellier, Institut Universitaire de Recherche Clinique, Montpellier, France Département d'informatique médicale, CHU de Nîmes, Nîmes, France. 5. Laboratoire Santé Travail Environnement, Univ. Bordeaux, ISPED, Bordeaux, France. 6. INSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, Bordeaux, France. 7. Département de neurologie, CHU de Caen, Caen, France. 8. Service de Neurochirurgie, CHU de Bordeaux, Bordeaux, France. 9. INSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, Bordeaux, France CHU de Bordeaux, Service d'information médicale, Bordeaux, France. 10. Laboratoire Santé Travail Environnement, Univ. Bordeaux, ISPED, Bordeaux, France INSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, Bordeaux, France Service de Médecine du Travail, CHU de Bordeaux, Bordeaux, France.
Abstract
UNLABELLED: The carcinogenic effect of radiofrequency electromagnetic fields in humans remains controversial. However, it has been suggested that they could be involved in the aetiology of some types of brain tumours. OBJECTIVES: The objective was to analyse the association between mobile phone exposure and primary central nervous system tumours (gliomas and meningiomas) in adults. METHODS: CERENAT is a multicenter case-control study carried out in four areas in France in 2004-2006. Data about mobile phone use were collected through a detailed questionnaire delivered in a face-to-face manner. Conditional logistic regression for matched sets was used to estimate adjusted ORs and 95% CIs. RESULTS: A total of 253 gliomas, 194 meningiomas and 892 matched controls selected from the local electoral rolls were analysed. No association with brain tumours was observed when comparing regular mobile phone users with non-users (OR=1.24; 95% CI 0.86 to 1.77 for gliomas, OR=0.90; 95% CI 0.61 to 1.34 for meningiomas). However, the positive association was statistically significant in the heaviest users when considering life-long cumulative duration (≥896 h, OR=2.89; 95% CI 1.41 to 5.93 for gliomas; OR=2.57; 95% CI 1.02 to 6.44 for meningiomas) and number of calls for gliomas (≥18,360 calls, OR=2.10, 95% CI 1.03 to 4.31). Risks were higher for gliomas, temporal tumours, occupational and urban mobile phone use. CONCLUSIONS: These additional data support previous findings concerning a possible association between heavy mobile phone use and brain tumours. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
UNLABELLED: The carcinogenic effect of radiofrequency electromagnetic fields in humans remains controversial. However, it has been suggested that they could be involved in the aetiology of some types of brain tumours. OBJECTIVES: The objective was to analyse the association between mobile phone exposure and primary central nervous system tumours (gliomas and meningiomas) in adults. METHODS:CERENAT is a multicenter case-control study carried out in four areas in France in 2004-2006. Data about mobile phone use were collected through a detailed questionnaire delivered in a face-to-face manner. Conditional logistic regression for matched sets was used to estimate adjusted ORs and 95% CIs. RESULTS: A total of 253 gliomas, 194 meningiomas and 892 matched controls selected from the local electoral rolls were analysed. No association with brain tumours was observed when comparing regular mobile phone users with non-users (OR=1.24; 95% CI 0.86 to 1.77 for gliomas, OR=0.90; 95% CI 0.61 to 1.34 for meningiomas). However, the positive association was statistically significant in the heaviest users when considering life-long cumulative duration (≥896 h, OR=2.89; 95% CI 1.41 to 5.93 for gliomas; OR=2.57; 95% CI 1.02 to 6.44 for meningiomas) and number of calls for gliomas (≥18,360 calls, OR=2.10, 95% CI 1.03 to 4.31). Risks were higher for gliomas, temporal tumours, occupational and urban mobile phone use. CONCLUSIONS: These additional data support previous findings concerning a possible association between heavy mobile phone use and brain tumours. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Authors: Jiajun Luo; Hang Li; Nicole C Deziel; Huang Huang; Nan Zhao; Shuangge Ma; Xin Ni; Robert Udelsman; Yawei Zhang Journal: Environ Res Date: 2019-12-06 Impact factor: 6.498
Authors: Sonia Bhala; Douglas R Stewart; Victoria Kennerley; Valentina I Petkov; Philip S Rosenberg; Ana F Best Journal: JNCI Cancer Spectr Date: 2021-04-08