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Literature DB >> 2481450

Liver tryptophan pyrrolase. A major determinant of the lower brain 5-hydroxytryptamine concentration in alcohol-preferring C57BL mice.

A A Badawy¹, C J Morgan, J Lane, K Dhaliwal, D M Bradley.

Abstract

The lower brain 5-hydroxytryptamine concentration in alcohol-preferring C57BL, compared with -non-preferring CBA, mice is caused by a decrease in circulating tryptophan availability to the brain secondarily to a higher liver tryptophan pyrrolase activity associated with a higher circulating corticosterone concentration. Activity or expression of liver tryptophan pyrrolase and/or their induction by glucocorticoids may be important biological determinants of predisposition to alcohol consumption.

Entities: Chemical Species

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Year: 1989 PMID： 2481450 PMCID： PMC1133620 DOI： 10.1042/bj2640597

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

25 in total

1. FLUOROMETRIC DETERMINATION OF CORTICOSTERONE AND CORTISOL IN 0.02-0.05 MILLILITERS OF PLASMA OR SUBMILLIGRAM SAMPLES OF ADRENAL TISSUE.

Authors: D GLICK; D VONREDLICH; S LEVINE
Journal: Endocrinology Date: 1964-04 Impact factor: 4.736

2. Regulation of rat liver tryptophan pyrrolase by its cofactor haem: Experiments with haematin and 5-aminolaevulinate and comparison with the substrate and hormonal mechanisms.

Authors: A A Badawy; M Evans
Journal: Biochem J Date: 1975-09 Impact factor: 3.857

Review 3. The functions and regulation of tryptophan pyrrolase.

Authors: A A Badawy
Journal: Life Sci Date: 1977-09-15 Impact factor: 5.037

4. Induction of tryptophan oxygenase and tyrosine aminotransferase in mice.

Authors: C B Monroe
Journal: Am J Physiol Date: 1968-06

5. Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat brain.

Authors: G Curzon; A R Green
Journal: Br J Pharmacol Date: 1970-07 Impact factor: 8.739

6. Animal liver tryptophan pyrrolases: Absence of apoenzyme and of hormonal induction mechanism from species sensitive to tryptophan toxicity.

Authors: A A Badawy; M Evans
Journal: Biochem J Date: 1976-07-15 Impact factor: 3.857

7. The effects of salicylate on the activity of rat liver tyrosine-2-oxoglutarate aminotransferase in vitro and in vivo.

Authors: A A Badawy
Journal: Biochem J Date: 1972-01 Impact factor: 3.857

8. Effects on plasma and brain tryptophan in the rat of drugs and hormones that influence the concentration of unesterified fatty acid in the plasma.

Authors: G Curzon; P J Knott
Journal: Br J Pharmacol Date: 1974-02 Impact factor: 8.739

9. Brain serotonin content: physiological dependence on plasma tryptophan levels.

Authors: J D Fernstrom; R J Wurtman
Journal: Science Date: 1971-07-09 Impact factor: 47.728

10. Brain regional and adrenal monoamine concentrations and behavioral responses to stress in alcohol-preferring AA and alcohol-avoiding ANA rats.

Authors: E R Korpi; J D Sinclair; P Kaheinen; T Viitamaa; K Hellevuo; K Kiianmaa
Journal: Alcohol Date: 1988 Sep-Oct Impact factor: 2.405

3 in total