Literature DB >> 2481443

The A-type receptor for platelet-derived growth factor mediates protein tyrosine phosphorylation, receptor transmodulation and a mitogenic response.

A Hammacher1, M Nistér, C H Heldin.   

Abstract

A clonal human glioma cell line, U-343 MGa 31L, which expresses the A-type but not the B-type receptor for platelet-derived growth factor (PDGF), was used in a functional study of the A-type receptor. PDGF-AA induced, in a dose- and time-dependent manner, phosphorylation on tyrosine residues of the receptor in metabolically labelled cells. The optimal dose was around 30 ng/ml; at 100 ng/ml, phosphorylation was maximal at 15 min and had almost returned to the control level after 60 min. The phosphorylation on tyrosine residues of the PDGF A-type receptor was stimulated by PDGF-AA, PDGF-AB and PDGF-BB; these isoforms also stimulated [3H]thymidine incorporation into U-343 MGa 31L cells. In addition, activation of the A-type PDGF receptor induced transmodulation of the epidermal growth factor receptor.

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Year:  1989        PMID： 2481443      PMCID： PMC1133541          DOI： 10.1042/bj2640015

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  40 in total

1.  Purification of the platelet-derived growth factor receptor by using an anti-phosphotyrosine antibody.

Authors:  T O Daniel; P M Tremble; A R Frackelton; L T Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

2.  Processing of the platelet-derived growth factor receptor. Biosynthetic and degradation studies using anti-receptor antibodies.

Authors:  M T Keating; L T Williams
Journal:  J Biol Chem       Date:  1987-06-05       Impact factor: 5.157

3.  A PDGF receptor domain essential for mitogenesis but not for many other responses to PDGF.

Authors:  J A Escobedo; L T Williams
Journal:  Nature       Date:  1988-09-01       Impact factor: 49.962

Review 4.  Platelet-derived growth factor.

Authors:  C H Heldin; A Wasteson; B Westermark
Journal:  Mol Cell Endocrinol       Date:  1985-03       Impact factor: 4.102

5.  Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors.

Authors:  Y Yarden; J A Escobedo; W J Kuang; T L Yang-Feng; T O Daniel; P M Tremble; E Y Chen; M E Ando; R N Harkins; U Francke
Journal:  Nature       Date:  1986 Sep 18-24       Impact factor: 49.962

6.  Improved medium for clonal growth of human diploid fibroblasts at low concentrations of serum protein.

Authors:  W L McKeehan; K A McKeehan; S L Hammond; R G Ham
Journal:  In Vitro       Date:  1977-07

7.  Growth factor-induced proliferation of human fibroblasts in serum-free culture depends on cell density and extracellular calcium concentration.

Authors:  C Betsholtz; B Westermark
Journal:  J Cell Physiol       Date:  1984-02       Impact factor: 6.384

8.  A glioma-derived PDGF A chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets.

Authors:  M Nistér; A Hammacher; K Mellström; A Siegbahn; L Rönnstrand; B Westermark; C H Heldin
Journal:  Cell       Date:  1988-03-25       Impact factor: 41.582

9.  Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor.

Authors:  K C Robbins; H N Antoniades; S G Devare; M W Hunkapiller; S A Aaronson
Journal:  Nature       Date:  1983 Oct 13-19       Impact factor: 49.962

10.  Interactions between the receptors for platelet-derived growth factor and epidermal growth factor.

Authors:  D F Bowen-Pope; P E Dicorleto; R Ross
Journal:  J Cell Biol       Date:  1983-03       Impact factor: 10.539
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  1 in total

1.  Platelet-derived growth factor activates phospholipase D and chemotactic responses in vascular smooth muscle cells.

Authors:  C J Welsh; K Schmeichel; K McBride
Journal:  In Vitro Cell Dev Biol       Date:  1991-05
  1 in total

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