Kasim Caglayan1, Bulent Gungor2, Hamza Cinar3, Nilsen Y Erdogan4, Bulent Koca2. 1. Faculty of Medicine, Department of Surgery, Bozok University, Yozgat, Turkey. Electronic address: kasimcaglayan@hotmail.com. 2. Faculty of Medicine, Department of Surgery, Ondokuz Mayis University, Samsun, Turkey. 3. Department of Surgery, Siirt Kurtalan State Hospital, Siirt, Turkey. 4. Department of Pathology, Taksim Training and Education Hospital, Istanbul, Turkey.
Abstract
BACKGROUND: We aimed to compare the effectiveness of linezolid in preventing intraperitoneal adhesions with hyaluronic acid + carboxymethylcellulose (Seprafilm). METHODS: Thirty rats were divided randomly into 3 groups: Group I (control), untreated; Group II (Seprafilm); and Group III (linezolid). All rats were sacrificed on the 14th day after surgery. Macroscopic adhesion, inflammation, and fibrosis were evaluated. RESULTS: The multiple comparisons between groups showed a statistically significant difference for adhesion. There were statistically significant differences between Group I and II and I and III, but no statistically significant difference between Group II and III. The multiple comparisons between the groups showed a statistically significant difference for inflammation and fibrosis. For inflammation and fibrosis, there was a statistically significant difference between Group I and II and I and III, but no statistically significant difference between Group II and III. CONCLUSION: The efficiency of linezolid in reducing the formation of intraperitoneal adhesions was statistically significant compared with the control group.
BACKGROUND: We aimed to compare the effectiveness of linezolid in preventing intraperitoneal adhesions with hyaluronic acid + carboxymethylcellulose (Seprafilm). METHODS: Thirty rats were divided randomly into 3 groups: Group I (control), untreated; Group II (Seprafilm); and Group III (linezolid). All rats were sacrificed on the 14th day after surgery. Macroscopic adhesion, inflammation, and fibrosis were evaluated. RESULTS: The multiple comparisons between groups showed a statistically significant difference for adhesion. There were statistically significant differences between Group I and II and I and III, but no statistically significant difference between Group II and III. The multiple comparisons between the groups showed a statistically significant difference for inflammation and fibrosis. For inflammation and fibrosis, there was a statistically significant difference between Group I and II and I and III, but no statistically significant difference between Group II and III. CONCLUSION: The efficiency of linezolid in reducing the formation of intraperitoneal adhesions was statistically significant compared with the control group.