Seok Kyo Seo1, Yeon Hong2, Bo Hyon Yun1, Seung Joo Chon1, Yeon Soo Jung1, Joo Hyun Park2, SiHyun Cho2, Young Sik Choi1, Byung Seok Lee3. 1. Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; Institute of Women׳s Life Medical Science, Seoul, Korea. 2. Institute of Women׳s Life Medical Science, Seoul, Korea; Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, 146-92 Dogok-dong, Gangnam-gu, Seoul 135-720, Korea. 3. Institute of Women׳s Life Medical Science, Seoul, Korea; Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, 146-92 Dogok-dong, Gangnam-gu, Seoul 135-720, Korea. Electronic address: dr222@yuhs.ac.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Red ginseng (RG) has been widely used to treat various diseases in East Asian countries. Previous studies have shown the anti-oxidative and anti-diabetic effects of RG. This study aimed to investigate the effects of RG on oxidative stress and insulin resistance in postmenopausal women. MATERIALS AND METHODS: We performed a randomized, double-blind, placebo-controlled trial in 82 postmenopausal women aged 45-60 years. Participants were randomized to receive 3g red ginseng daily or placebo for 12 weeks. Antioxidant enzymes activity (superoxide dismutase, glutathione peroxidase) and oxidative stress markers (malondialdehyde, 8-hydroxydeoxyguanosine) were assessed, and the homeostatic model assessment of insulin resistance index was calculated at the baseline and at the end of the trial. RESULTS: A total of 71 postmenopausal women completed the study. Serum superoxide dismutase activity was significantly increased after the 12-week RG supplementation (P<0.001), and these changes were statistically significant compared with the placebo group (P=0.004). Serum malondialdehyde levels showed a tendency to decrease after the 12-week RG supplementation (P=0.001), but these changes were not statistically significant compared with the placebo group (P=0.064). No statistically significant changes in serum glutathione peroxidase and 8-hydroxydeoxyguanosine were noted. Further, RG supplementation showed no effects on fasting glucose, fasting insulin, and insulin resistance. CONCLUSIONS: The results suggest that RG may reduce oxidative stress by increasing antioxidant enzyme activity in postmenopausal women.
RCT Entities:
ETHNOPHARMACOLOGICAL RELEVANCE: Red ginseng (RG) has been widely used to treat various diseases in East Asian countries. Previous studies have shown the anti-oxidative and anti-diabetic effects of RG. This study aimed to investigate the effects of RG on oxidative stress and insulin resistance in postmenopausal women. MATERIALS AND METHODS: We performed a randomized, double-blind, placebo-controlled trial in 82 postmenopausal women aged 45-60 years. Participants were randomized to receive 3g red ginseng daily or placebo for 12 weeks. Antioxidant enzymes activity (superoxide dismutase, glutathione peroxidase) and oxidative stress markers (malondialdehyde, 8-hydroxydeoxyguanosine) were assessed, and the homeostatic model assessment of insulin resistance index was calculated at the baseline and at the end of the trial. RESULTS: A total of 71 postmenopausal women completed the study. Serum superoxide dismutase activity was significantly increased after the 12-week RG supplementation (P<0.001), and these changes were statistically significant compared with the placebo group (P=0.004). Serum malondialdehyde levels showed a tendency to decrease after the 12-week RG supplementation (P=0.001), but these changes were not statistically significant compared with the placebo group (P=0.064). No statistically significant changes in serum glutathione peroxidase and 8-hydroxydeoxyguanosine were noted. Further, RG supplementation showed no effects on fasting glucose, fasting insulin, and insulin resistance. CONCLUSIONS: The results suggest that RG may reduce oxidative stress by increasing antioxidant enzyme activity in postmenopausal women.
Authors: Sun Hee Hyun; Chang-Kyun Han; Seung-Ho So; Soo Kyung Park; Chae-Kyu Park; Gyo In; Ji Young Lee Journal: J Ginseng Res Date: 2021-12-11 Impact factor: 5.735
Authors: Jin Woo Lee; Eun Jin Mo; Ji Eun Choi; Yang Hee Jo; Hari Jang; Ji Yeon Jeong; Qinghao Jin; Hee Nam Chung; Bang Yeon Hwang; Mi Kyeong Lee Journal: J Ginseng Res Date: 2015-08-20 Impact factor: 6.060