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Literature DB >> 2481236

Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel.

U B Kaupp¹, T Niidome, T Tanabe, S Terada, W Bönigk, W Stühmer, N J Cook, K Kangawa, H Matsuo, T Hirose.

Abstract

The complete amino-acid sequence of the cyclic GMP-gated channel from bovine retinal rod photoreceptors, deduced by cloning and sequencing its complementary DNA, shows that the protein contains several putative transmembrane segments, followed by a region that is similar to the cyclic GMP-binding domains of cyclic GMP-dependent protein kinase. Expression of the complementary DNA produces cyclic GMP-gated channel activity in Xenopus oocytes.

Entities: Chemical Gene Species

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Year: 1989 PMID： 2481236 DOI： 10.1038/342762a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

198 in total

1. Ligand sensitivity of the 2 subunit from the bovine cone cGMP-gated channel is modulated by protein kinase C but not by calmodulin.

Authors: F Müller; M Vantler; D Weitz; E Eismann; M Zoche; K W Koch; U B Kaupp
Journal: J Physiol Date: 2001-04-15 Impact factor: 5.182

2. Constraining the subunit order of rod cyclic nucleotide-gated channels reveals a diagonal arrangement of like subunits.

Authors: Y He; M Ruiz; J W Karpen
Journal: Proc Natl Acad Sci U S A Date: 2000-01-18 Impact factor: 11.205

10. Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa.

Authors: T P Dryja; J T Finn; Y W Peng; T L McGee; E L Berson; K W Yau
Journal: Proc Natl Acad Sci U S A Date: 1995-10-24 Impact factor: 11.205

Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel.

1. Ligand sensitivity of the 2 subunit from the bovine cone cGMP-gated channel is modulated by protein kinase C but not by calmodulin.

2. Constraining the subunit order of rod cyclic nucleotide-gated channels reveals a diagonal arrangement of like subunits.

3. Functional characterization of the C-terminus of the human ether-à-go-go-related gene K(+) channel (HERG).

4. Mechanism of calcium/calmodulin inhibition of rod cyclic nucleotide-gated channels.

5. Mechanism of allosteric modulation of rod cyclic nucleotide-gated channels.

6. Allosteric gating of a large conductance Ca-activated K+ channel.

7. Single-channel properties of ionic channels gated by cyclic nucleotides.

8. The multi-ion nature of the cGMP-gated channel from vertebrate rods.

9. Subunit interactions in coordination of Ni2+ in cyclic nucleotide-gated channels.

10. Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa.