Literature DB >> 24811324

Hepatoprotective coumarins and secoiridoids from Hydrangea paniculata.

Jing Shi1, Chuang-Jun Li2, Jing-Zhi Yang2, Jie Ma2, Chao Wang2, Jia Tang2, Yan Li2, Hui Chen2, Dong-Ming Zhang3.   

Abstract

Three new coumarin glucosides (1, 3, 4), and a new secoiridoid glucoside (2), together with one known secoiridoid glucoside (5), were isolated from the stems of Hydrangea paniculata. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR, MS and CD spectra. At 10 μM, compounds 1-5 showed hepatoprotective activities against DL-galactosamine-induced toxicity in HL-7702 cells.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Coumarins; Hepatoprotective activity; Hydrangea paniculata; Secoiridoids

Mesh：

Substances：

Year:  2014        PMID： 24811324     DOI： 10.1016/j.fitote.2014.04.015

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  5 in total

1.  Separation of Dihydro-Isocoumarins and Dihydro-Stilbenoids from Hydrangea macrophylla ssp. serrata by Use of Counter-Current Chromatography.

Authors:  Johannes Wellmann; Beate Hartmann; Esther-Corinna Schwarze; Silke Hillebrand; Stephan I Brueckner; Jakob Ley; Gerold Jerz; Peter Winterhalter
Journal:  Molecules       Date:  2022-05-26       Impact factor: 4.927

2.  Total Coumarins from Hydrangea paniculata Show Renal Protective Effects in Lipopolysaccharide-Induced Acute Kidney Injury via Anti-inflammatory and Antioxidant Activities.

Authors:  Sen Zhang; Jie Ma; Li Sheng; Dongming Zhang; Xiaoguang Chen; Jingzhi Yang; Dongjie Wang
Journal:  Front Pharmacol       Date:  2017-12-14       Impact factor: 5.810

3.  Total Coumarins from Hydrangea paniculata Protect against Cisplatin-Induced Acute Kidney Damage in Mice by Suppressing Renal Inflammation and Apoptosis.

Authors:  Zhang Sen; Ma Jie; Yang Jingzhi; Wang Dongjie; Zhang Dongming; Chen Xiaoguang
Journal:  Evid Based Complement Alternat Med       Date:  2017-03-06       Impact factor: 2.629

4.  Hepatoprotective standardized EtOH-water extract from the seeds of Fraxinus rhynchophylla Hance.

Authors:  Sen Guo; Tiantian Guo; Ni Cheng; Qingchao Liu; Yunting Zhang; Lu Bai; Li Zhang; Wei Cao; Chi-Tang Ho; Naisheng Bai
Journal:  J Tradit Complement Med       Date:  2016-06-01

5.  New Phenylpropanoid and Coumarin Glycosides from the Stems of Hydrangea paniculata Sieb.

Authors:  Jie Ma; Chuang-Jun Li; Jing-Zhi Yang; Hua Sun; Dong-Ming Zhang
Journal:  Molecules       Date:  2017-01-18       Impact factor: 4.411
  5 in total

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