Carsten Bøcker Pedersen1, Ole Mors2, Aksel Bertelsen3, Berit Lindum Waltoft4, Esben Agerbo1, John J McGrath5, Preben Bo Mortensen1, William W Eaton6. 1. National Centre for Register-Based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark2Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark3The Lundbeck Foundation Initiative for Integrative Psychiatric. 2. The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark4Research Department P, Aarhus University Hospital, Risskov, Denmark. 3. Research Department P, Aarhus University Hospital, Risskov, Denmark. 4. National Centre for Register-Based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark3The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark. 5. Queensland Brain Institute, The University of Queensland, St Lucia, Australia6Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Richlands, Australia. 6. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Abstract
IMPORTANCE: Understanding the epidemiologic profile of the life course of mental disorders is fundamental for research and planning for health care. Although previous studies have used population surveys, informative and complementary estimates can be derived from population-based registers. OBJECTIVE: To derive comprehensive and precise estimates of the incidence rate of and lifetime risk for any mental disorder and a range of specific mental disorders. DESIGN, SETTING, AND PARTICIPANTS: We conducted a follow-up study of all Danish residents (5.6 million persons), to whom all treatment is provided by the government health care system without charge to the patient, from January 1, 2000, through December 31, 2012 (total follow-up, 59.5 million person-years). During the study period, 320,543 persons received first lifetime treatment in a psychiatric setting for any mental disorder; 489,006 persons were censored owing to death; and 69,987 persons were censored owing to emigration. Specific categories of mental disorders investigated included organic mental disorders, substance abuse disorders, schizophrenia, mood disorders, anxiety, eating disorders, personality disorders, mental retardation, pervasive developmental disorders, and behavioral and emotional disorders. EXPOSURES: Age and sex. MAIN OUTCOMES AND MEASURES: Sex- and age-specific incidence rates and cumulative incidences and sex-specific lifetime risks. RESULTS: During the course of life, 37.66% of females (95% CI, 37.52%-37.80%) and 32.05% of males (31.91%-32.19%) received their first treatment in a psychiatric setting for any mental disorder. The occurrence of mental disorders varied markedly between diagnostic categories and by sex and age. The sex- and age-specific incidence rates for many mental disorders had a single peak incidence rate during the second and third decades of life. Some disorders had a second peak in the sex- and age-specific incidence rate later in life. CONCLUSIONS AND RELEVANCE: This nationwide study provides a first comprehensive assessment of the lifetime risks for treated mental disorders. Approximately one-third of the Danish population received treatment for mental disorders. The distinct signatures of the different mental disorders with respect to sex and age have important implications for service planning and etiologic research.
IMPORTANCE: Understanding the epidemiologic profile of the life course of mental disorders is fundamental for research and planning for health care. Although previous studies have used population surveys, informative and complementary estimates can be derived from population-based registers. OBJECTIVE: To derive comprehensive and precise estimates of the incidence rate of and lifetime risk for any mental disorder and a range of specific mental disorders. DESIGN, SETTING, AND PARTICIPANTS: We conducted a follow-up study of all Danish residents (5.6 million persons), to whom all treatment is provided by the government health care system without charge to the patient, from January 1, 2000, through December 31, 2012 (total follow-up, 59.5 million person-years). During the study period, 320,543 persons received first lifetime treatment in a psychiatric setting for any mental disorder; 489,006 persons were censored owing to death; and 69,987 persons were censored owing to emigration. Specific categories of mental disorders investigated included organic mental disorders, substance abuse disorders, schizophrenia, mood disorders, anxiety, eating disorders, personality disorders, mental retardation, pervasive developmental disorders, and behavioral and emotional disorders. EXPOSURES: Age and sex. MAIN OUTCOMES AND MEASURES: Sex- and age-specific incidence rates and cumulative incidences and sex-specific lifetime risks. RESULTS: During the course of life, 37.66% of females (95% CI, 37.52%-37.80%) and 32.05% of males (31.91%-32.19%) received their first treatment in a psychiatric setting for any mental disorder. The occurrence of mental disorders varied markedly between diagnostic categories and by sex and age. The sex- and age-specific incidence rates for many mental disorders had a single peak incidence rate during the second and third decades of life. Some disorders had a second peak in the sex- and age-specific incidence rate later in life. CONCLUSIONS AND RELEVANCE: This nationwide study provides a first comprehensive assessment of the lifetime risks for treated mental disorders. Approximately one-third of the Danish population received treatment for mental disorders. The distinct signatures of the different mental disorders with respect to sex and age have important implications for service planning and etiologic research.
Authors: Ole Köhler-Forsberg; Liselotte Petersen; Christiane Gasse; Preben B Mortensen; Soren Dalsgaard; Robert H Yolken; Ole Mors; Michael E Benros Journal: JAMA Psychiatry Date: 2019-03-01 Impact factor: 21.596
Authors: S M Meier; E Agerbo; R Maier; C B Pedersen; M Lang; J Grove; M V Hollegaard; D Demontis; B B Trabjerg; C Hjorthøj; S Ripke; F Degenhardt; M M Nöthen; D Rujescu; W Maier; T Werge; O Mors; D M Hougaard; A D Børglum; N R Wray; M Rietschel; M Nordentoft; P B Mortensen; M Mattheisen Journal: Mol Psychiatry Date: 2015-09-01 Impact factor: 15.992
Authors: Kimberlie Dean; Thomas M Laursen; Carsten B Pedersen; Roger T Webb; Preben B Mortensen; Esben Agerbo Journal: JAMA Psychiatry Date: 2018-07-01 Impact factor: 21.596
Authors: Anne Ranning; Michael E Benros; Anne A E Thorup; Kirstine Agnete Davidsen; Carsten Hjorthøj; Merete Nordentoft; Thomas Munk Laursen; Holger Sørensen Journal: Schizophr Bull Date: 2020-01-04 Impact factor: 9.306
Authors: Oleguer Plana-Ripoll; Carsten Bøcker Pedersen; Yan Holtz; Michael E Benros; Søren Dalsgaard; Peter de Jonge; Chun Chieh Fan; Louisa Degenhardt; Andrea Ganna; Aja Neergaard Greve; Jane Gunn; Kim Moesgaard Iburg; Lars Vedel Kessing; Brian K Lee; Carmen C W Lim; Ole Mors; Merete Nordentoft; Anders Prior; Annelieke M Roest; Sukanta Saha; Andrew Schork; James G Scott; Kate M Scott; Terry Stedman; Holger J Sørensen; Thomas Werge; Harvey A Whiteford; Thomas Munk Laursen; Esben Agerbo; Ronald C Kessler; Preben Bo Mortensen; John J McGrath Journal: JAMA Psychiatry Date: 2019-03-01 Impact factor: 21.596
Authors: Oleguer Plana-Ripoll; Katherine L Musliner; Søren Dalsgaard; Natalie C Momen; Nanna Weye; Maria K Christensen; Esben Agerbo; Kim Moesgaard Iburg; Thomas Munk Laursen; Preben Bo Mortensen; Carsten Bøcker Pedersen; Liselotte Vogdrup Petersen; Damian F Santomauro; Bjarni J Vilhjálmsson; Harvey A Whiteford; John J McGrath Journal: World Psychiatry Date: 2020-10 Impact factor: 49.548
Authors: Snehal N Shah; Alan Fossa; Abigail S Steiner; John Kane; Jonathan I Levy; Gary Adamkiewicz; Willie Mae Bennett-Fripp; Margaret Reid Journal: J Urban Health Date: 2018-10 Impact factor: 3.671
Authors: Florian Walter; Matthew J Carr; Pearl L H Mok; Sussie Antonsen; Carsten B Pedersen; Jenny Shaw; Roger T Webb Journal: J Clin Psychiatry Date: 2018-10-02 Impact factor: 4.384