Patricia Gassó1, Marie A Ritter2, Sergi Mas3, Amalia Lafuente4. 1. Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain. 2. Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Spain. 3. Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain. 4. Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain amalialafuente@ub.edu.
Abstract
INTRODUCTION: ABO rs495828 polymorphism has recently been associated with risk of hypertension and cough induced by angiotensin-converting enzyme (ACE) inhibitors, which could be due to low ACE plasma activity. To study whether ABO rs495828 is associated with ACE activity. The association between ABO genotype and phenotype, and differences in ACE activity between the ABO phenotype groups were also studied. SUBJECTS AND METHODS: We genotyped 168 subjects for rs495828. ACE plasma activity and ABO histo-blood group were measured in all minor allele homozygous subjects (TT) that agreed to participate in the study (n=8) and in age- and gender-matched heterozygous subjects (GT; n=8) and major allele homozygous subjects (GG; n=8). RESULTS: A non-significant trend was found in ACE activity among rs495828 genotype groups; however the polymorphism was significantly associated with ABO phenotype (p=0.007), which in turn was associated with ACE activity (p=0.029). CONCLUSION: These results provide new evidence for the ABO-ACE relationship. Although the genetic marker studied here may be involved somehow, ABO phenotype is shown to be a better predictor of ACE plasma activity.
INTRODUCTION:ABOrs495828 polymorphism has recently been associated with risk of hypertension and cough induced by angiotensin-converting enzyme (ACE) inhibitors, which could be due to low ACE plasma activity. To study whether ABOrs495828 is associated with ACE activity. The association between ABO genotype and phenotype, and differences in ACE activity between the ABO phenotype groups were also studied. SUBJECTS AND METHODS: We genotyped 168 subjects for rs495828. ACE plasma activity and ABO histo-blood group were measured in all minor allele homozygous subjects (TT) that agreed to participate in the study (n=8) and in age- and gender-matched heterozygous subjects (GT; n=8) and major allele homozygous subjects (GG; n=8). RESULTS: A non-significant trend was found in ACE activity among rs495828 genotype groups; however the polymorphism was significantly associated with ABO phenotype (p=0.007), which in turn was associated with ACE activity (p=0.029). CONCLUSION: These results provide new evidence for the ABO-ACE relationship. Although the genetic marker studied here may be involved somehow, ABO phenotype is shown to be a better predictor of ACE plasma activity.
Authors: Daniela Milani; Lorenzo Caruso; Enrico Zauli; Adi Mohammed Al Owaifeer; Paola Secchiero; Giorgio Zauli; Donato Gemmati; Veronica Tisato Journal: Front Pharmacol Date: 2022-05-27 Impact factor: 5.988
Authors: David J Hermel; Samantha R Spierling Bagsic; Carrie L Costantini; James R Mason; Zhubin J Gahvari; Alan Saven Journal: Future Sci OA Date: 2021-06-12