Literature DB >> 24801249

Nano-chemotherapeutics: maximising lymphatic drug exposure to improve the treatment of lymph-metastatic cancers.

Gemma M Ryan1, Lisa M Kaminskas1, Christopher J H Porter2.   

Abstract

Nano-sized drug delivery systems incorporating chemotherapeutic drugs ("nano-chemotherapeutics") have been widely employed for the treatment of solid tumours. The dimensions of nanoparticulate drug delivery systems also make them ideal vectors for improving drug exposure to the lymphatic system, potentially enhancing the treatment of lymph-resident metastases. This review examines the physical properties of nanoparticulate drug delivery systems that promote lymphatic exposure and lymph node retention, and discusses methods for improving lymphatic access. Drug delivery systems that have been investigated for the treatment of lymph node metastasis are also reviewed, and recent advances towards active targeting approaches for lymphatic metastases highlighted.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Chemotherapeutic; Drug delivery systems; Lymph node; Lymphatic; Metastasis

Mesh：

Substances：

Year:  2014        PMID： 24801249     DOI： 10.1016/j.jconrel.2014.04.051

Source DB:  PubMed          Journal:  J Control Release        ISSN： 0168-3659            Impact factor:   9.776


  18 in total

1.  A Comparison of the Pharmacokinetics and Pulmonary Lymphatic Exposure of a Generation 4 PEGylated Dendrimer Following Intravenous and Aerosol Administration to Rats and Sheep.

Authors:  Gemma M Ryan; Robert J Bischof; Perenlei Enkhbaatar; Victoria M McLeod; Linda J Chan; Seth A Jones; David J Owen; Christopher J H Porter; Lisa M Kaminskas
Journal:  Pharm Res       Date:  2015-10-20       Impact factor: 4.200

Review 2.  From sewer to saviour - targeting the lymphatic system to promote drug exposure and activity.

Authors:  Natalie L Trevaskis; Lisa M Kaminskas; Christopher J H Porter
Journal:  Nat Rev Drug Discov       Date:  2015-10-16       Impact factor: 84.694

3.  Intelligent Nanoparticles for Advanced Drug Delivery in Cancer Treatment.

Authors:  David S Spencer; Amey S Puranik; Nicholas A Peppas
Journal:  Curr Opin Chem Eng       Date:  2015-02       Impact factor: 5.163

Review 4.  Exploiting lymphatic vessels for immunomodulation: Rationale, opportunities, and challenges.

Authors:  Katharina Maisel; Maria Stella Sasso; Lambert Potin; Melody A Swartz
Journal:  Adv Drug Deliv Rev       Date:  2017-07-08       Impact factor: 15.470

Review 5.  Nanodrug formulations to enhance HIV drug exposure in lymphoid tissues and cells: clinical significance and potential impact on treatment and eradication of HIV/AIDS.

Authors:  Jingwei Shao; John C Kraft; Bowen Li; Jesse Yu; Jennifer Freeling; Josefin Koehn; Rodney Jy Ho
Journal:  Nanomedicine (Lond)       Date:  2016-02-19       Impact factor: 5.307

Review 6.  Nanoparticle-based approaches to target the lymphatic system for antitumor treatment.

Authors:  Xingzhou Peng; Junjie Wang; Feifan Zhou; Qian Liu; Zhihong Zhang
Journal:  Cell Mol Life Sci       Date:  2021-05-08       Impact factor: 9.261

7.  Lymphatic Transport and Lymph Node Location of Microspheres Subcutaneously Injected in the Vicinity of Tumors in a Rabbit Model of Breast Cancer.

Authors:  Florentina Pascale; Laurent Bédouet; Afchine Fazel; Julien Namur; Saida Homayra Ghegediban; Isabelle Schwartz Cornil; Michel Wassef; Laurence Moine; Alexandre Laurent
Journal:  Pharm Res       Date:  2018-08-15       Impact factor: 4.200

Review 8.  Targeting tumor metastases: Drug delivery mechanisms and technologies.

Authors:  Vidya Ganapathy; Prabhas V Moghe; Charles M Roth
Journal:  J Control Release       Date:  2015-09-25       Impact factor: 9.776

9.  Quantitation of lymphatic transport mechanism and barrier influences on lymph node-resident leukocyte access to lymph-borne macromolecules and drug delivery systems.

Authors:  Paul A Archer; Lauren F Sestito; Margaret P Manspeaker; Meghan J O'Melia; Nathan A Rohner; Alex Schudel; Yajun Mei; Susan N Thomas
Journal:  Drug Deliv Transl Res       Date:  2021-06-24       Impact factor: 4.617

10.  The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats.

Authors:  Zhaoling Zheng; YanHua Sun; Ziliang Liu; Mingqin Zhang; Chunqing Li; Hui Cai
Journal:  Drug Des Devel Ther       Date:  2015-08-27       Impact factor: 4.162
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