BACKGROUND: Deceased kidney donors are increasingly "marginal," and many have risk factors for acute kidney injury (AKI) that may impact on subsequent renal transplant outcome. Despite this, determining the presence of AKI at the time of deceased organ donation remains difficult. METHODS: Urine samples from 182 brainstem dead multi-organ donors (all of whom donated hearts that were transplanted) were analyzed for a Luminex(™) panel of biomarkers linked with AKI. This included KIM-1, NGAL, IFN-γ, TNF-α, cystatin C, Fractalkine and vascular endothelial growth factor. Levels were correlated to early renal transplant outcomes, most specifically delayed graft function. RESULTS: Donor urinary KIM-1 levels were significantly higher in donors whose kidneys displayed aberrant early function (p = 0.011). Fractalkine levels showed a trend toward elevation in such donors but uncorrected this did not attain significance. No correlation occurred with the remaining biomarkers. CONCLUSIONS: KIM-1 appears to show promise as a marker for AKI in deceased cardiac organ donors. The availability of a lateral flow device (Renastick(™) ) for KIM-1 that also demonstrates higher urinary KIM-1 levels in donors whose kidneys show aberrant initial function (p = 0.03), makes KIM-1 a potential indicator of AKI that may merit further evaluation for its application at the donor bedside.
BACKGROUND: Deceased kidney donors are increasingly "marginal," and many have risk factors for acute kidney injury (AKI) that may impact on subsequent renal transplant outcome. Despite this, determining the presence of AKI at the time of deceased organ donation remains difficult. METHODS: Urine samples from 182 brainstem dead multi-organ donors (all of whom donated hearts that were transplanted) were analyzed for a Luminex(™) panel of biomarkers linked with AKI. This included KIM-1, NGAL, IFN-γ, TNF-α, cystatin C, Fractalkine and vascular endothelial growth factor. Levels were correlated to early renal transplant outcomes, most specifically delayed graft function. RESULTS:Donor urinary KIM-1 levels were significantly higher in donors whose kidneys displayed aberrant early function (p = 0.011). Fractalkine levels showed a trend toward elevation in such donors but uncorrected this did not attain significance. No correlation occurred with the remaining biomarkers. CONCLUSIONS:KIM-1 appears to show promise as a marker for AKI in deceased cardiac organ donors. The availability of a lateral flow device (Renastick(™) ) for KIM-1 that also demonstrates higher urinary KIM-1 levels in donors whose kidneys show aberrant initial function (p = 0.03), makes KIM-1 a potential indicator of AKI that may merit further evaluation for its application at the donor bedside.
Authors: Bas W M van Balkom; Hendrik Gremmels; Liselotte S S Ooms; Raechel J Toorop; Frank J M F Dor; Olivier G de Jong; Laura A Michielsen; Gert J de Borst; Wilco de Jager; Alferso C Abrahams; Arjan D van Zuilen; Marianne C Verhaar Journal: Clin J Am Soc Nephrol Date: 2017-05-08 Impact factor: 8.237
Authors: I E Hall; B Schröppel; M D Doshi; J Ficek; F L Weng; R D Hasz; H Thiessen-Philbrook; P P Reese; C R Parikh Journal: Am J Transplant Date: 2015-03-11 Impact factor: 8.086
Authors: Hendrik Gremmels; Olivier G de Jong; Raechel J Toorop; Laura Michielsen; Arjan D van Zuilen; Alexander V Vlassov; Marianne C Verhaar; Bas W M van Balkom Journal: Transplant Direct Date: 2019-08-12
Authors: Jacob S Stevens; Katherine Xu; Alexa Corker; Tejashree S Gopal; Osman R Sayan; Erin P Geraghty; Andrew M Yaeh; Yaagnik D Kosuri; John R Burton; Saul V Lincoln; Miriam P Callahan; Rebecca K Breheney; Andrew S Beenken; Juliana N Gamino; Ariel E Felman; Anjali Gehani; Hayley A Giordano; Aileen Gozali; Eddie F Guerrero Herrera; Britney A Hatcher; Lena A Kheir; Yuanji Li; Erika K Mitsui; Jae I Nha; Alexander T Sayan; Samuel J Spaiser; Siddarth Arumugam; Samuel K Sia; Kristen L King; Sumit Mohan; Jonathan Barasch Journal: Kidney Int Rep Date: 2020-09-18