Literature DB >> 24798985

Principles and reality of proton therapy treatment allocation.

Justin E Bekelman1, David A Asch2, Zelig Tochner3, Joseph Friedberg4, David J Vaughn5, Ellen Rash3, Kevin Raksowski6, Stephen M Hahn3.   

Abstract

PURPOSE: To present the principles and rationale of the Proton Priority System (PROPS), a priority points framework that assigns higher scores to patients thought to more likely benefit from proton therapy, and the distribution of PROPS scores by patient characteristics METHODS AND MATERIALS: We performed multivariable logistic regression to evaluate the association between PROPS scores and receipt of proton therapy, adjusted for insurance status, gender, race, geography, and the domains that inform the PROPS score.
RESULTS: Among 1529 adult patients considered for proton therapy prioritization during our Center's ramp-up phase of treatment availability, PROPS scores varied by age, diagnosis, site, and other PROPS domains. In adjusted analyses, receipt of proton therapy was lower for patients with non-Medicare relative to Medicare health insurance (commercial vs Medicare: adjusted odds ratio [OR] 0.47, 95% confidence interval [CI] 0.34-0.64; managed care vs Medicare: OR 0.40, 95% CI 0.28-0.56; Medicaid vs Medicare: OR 0.24, 95% CI 0.13-0.44). Proton Priority System score and age were not significantly associated with receipt of proton therapy.
CONCLUSIONS: The Proton Priority System is a rationally designed and transparent system for allocation of proton therapy slots based on the best available evidence and expert opinion. Because the actual allocation of treatment slots depends mostly on insurance status, payers may consider incorporating PROPS, or its underlying principles, into proton therapy coverage policies.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID: 24798985      PMCID: PMC4278661          DOI: 10.1016/j.ijrobp.2014.03.023

Source DB:  PubMed          Journal:  Int J Radiat Oncol Biol Phys        ISSN: 0360-3016            Impact factor:   7.038


  16 in total

1.  Principles of justice in health care rationing.

Authors:  R Cookson; P Dolan
Journal:  J Med Ethics       Date:  2000-10       Impact factor: 2.903

2.  Real-time rationing of scarce resources: the Northeast Proton Therapy Center experience.

Authors:  Reshma Jagsi; Thomas F DeLaney; Karen Donelan; Nancy J Tarbell
Journal:  J Clin Oncol       Date:  2004-06-01       Impact factor: 44.544

Review 3.  Rationing critical care beds: a systematic review.

Authors:  Tasnim Sinuff; Kamayar Kahnamoui; Deborah J Cook; John M Luce; Mitchell M Levy
Journal:  Crit Care Med       Date:  2004-07       Impact factor: 7.598

4.  The proton beam debate: are facilities outstripping the evidence?

Authors:  Merrill Goozner
Journal:  J Natl Cancer Inst       Date:  2010-03-25       Impact factor: 13.506

5.  How Medicare could use comparative effectiveness research in deciding on new coverage and reimbursement.

Authors:  Steven D Pearson; Peter B Bach
Journal:  Health Aff (Millwood)       Date:  2010-10       Impact factor: 6.301

6.  Principles for allocation of scarce medical interventions.

Authors:  Govind Persad; Alan Wertheimer; Ezekiel J Emanuel
Journal:  Lancet       Date:  2009-01-31       Impact factor: 79.321

7.  Limits on Medicare's ability to control rising spending on cancer drugs.

Authors:  Peter B Bach
Journal:  N Engl J Med       Date:  2009-01-27       Impact factor: 91.245

Review 8.  Proton therapy - a systematic review of clinical effectiveness.

Authors:  Dag Rune Olsen; Oyvind S Bruland; Gunilla Frykholm; Inger Natvig Norderhaug
Journal:  Radiother Oncol       Date:  2007-05-11       Impact factor: 6.280

9.  Liver transplantation for hepatocellular carcinoma: impact of the MELD allocation system and predictors of survival.

Authors:  George N Ioannou; James D Perkins; Robert L Carithers
Journal:  Gastroenterology       Date:  2008-02-13       Impact factor: 22.682

10.  Impact of the MELD score on waiting time and disease severity in liver transplantation in United States veterans.

Authors:  Jawad Ahmad; Kathy K Downey; Mohamed Akoad; Thomas V Cacciarelli
Journal:  Liver Transpl       Date:  2007-11       Impact factor: 5.799

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  8 in total

Review 1.  Proton Therapy for Squamous Cell Carcinoma of the Head and Neck: Early Clinical Experience and Current Challenges.

Authors:  Sandra Nuyts; Heleen Bollen; Sweet Ping Ng; June Corry; Avraham Eisbruch; William M Mendenhall; Robert Smee; Primoz Strojan; Wai Tong Ng; Alfio Ferlito
Journal:  Cancers (Basel)       Date:  2022-05-24       Impact factor: 6.575

2.  Variations in Proton Therapy Coverage in the State of Texas: Defining Medical Necessity for a Safe and Effective Treatment.

Authors:  Nikhil G Thaker; Ankit Agarwal; Matthew Palmer; Rosemarie Hontiveros; Stephen M Hahn; Bruce D Minsky; Ronald Walters; John Bingham; Thomas W Feeley; Thomas A Buchholz; Steven J Frank
Journal:  Int J Part Ther       Date:  2016-03-24

Review 3.  Proton radiotherapy for pediatric tumors: review of first clinical results.

Authors:  Barbara Rombi; Sabina Vennarini; Lorenzo Vinante; Daniele Ravanelli; Maurizio Amichetti
Journal:  Ital J Pediatr       Date:  2014-09-26       Impact factor: 2.638

4.  Sociodemographic disparities in the utilization of proton therapy for prostate cancer at an urban academic center.

Authors:  Kristina D Woodhouse; Wei-Ting Hwang; Neha Vapiwala; Akansha Jain; Xingmei Wang; Stefan Both; Meera Shah; Marquise Frazier; Peter Gabriel; John P Christodouleas; Zelig Tochner; Curtiland Deville
Journal:  Adv Radiat Oncol       Date:  2017-01-18

Review 5.  [Progress on the Therapeutic Approaches for Malignant Tumor 
with Superior Vena Cava Syndrome].

Authors:  Xiangzheng Liu; Shijie Zhang; Jian Li
Journal:  Zhongguo Fei Ai Za Zhi       Date:  2016-11-20

6.  Patient Prioritization for Proton Beam Therapy in a Cost-neutral Payer Environment: Use of the Clinical Benefit Score for Resource Allocation.

Authors:  Ankur M Sharma; Rahul Khairnar; Emily S Kowalski; Jill Remick; Elizabeth M Nichols; Pranshu Mohindra; Torunn Yock; William Regine; Mark V Mishra
Journal:  Cureus       Date:  2019-09-19

7.  Association of Race With Receipt of Proton Beam Therapy for Patients With Newly Diagnosed Cancer in the US, 2004-2018.

Authors:  Leticia M Nogueira; Helmneh M Sineshaw; Ahmedin Jemal; Craig E Pollack; Jason A Efstathiou; K Robin Yabroff
Journal:  JAMA Netw Open       Date:  2022-04-01

Review 8.  Review of evolving etiologies, implications and treatment strategies for the superior vena cava syndrome.

Authors:  Christopher Straka; James Ying; Feng-Ming Kong; Christopher D Willey; Joseph Kaminski; D W Nathan Kim
Journal:  Springerplus       Date:  2016-02-29
  8 in total

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