Literature DB >> 24798281

Anti-Candida activity of fluoxetine alone and combined with fluconazole: a synergistic action against fluconazole-resistant strains.

Ana S Oliveira1, Carlos A Gaspar1, Rita Palmeira-de-Oliveira2, José Martinez-de-Oliveira3, Ana Palmeira-de-Oliveira4.   

Abstract

The purpose of this work was to determine the antimicrobial activity of fluoxetine, alone and combined with fluconazole, against 29 Candida strains isolated from patients with vulvovaginal candidiasis. MIC and minimum lethal concentration values ranged from 9.8 to 625 μg/ml for all strains tested. The combination of fluconazole with fluoxetine resulted in synergistic activity against six Candida strains, with fractional inhibitory index (FIX) values between 0.15 and 0.31. An indifferent effect was found for the remaining strains, with FIX values between 0.63 and 1.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24798281      PMCID： PMC4068595          DOI： 10.1128/AAC.02623-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Antifungal activity against Candida species of the selective serotonin-reuptake inhibitor, sertraline.

Authors:  C Lass-Flörl; M P Dierich; D Fuchs; E Semenitz; M Ledochowski
Journal:  Clin Infect Dis       Date:  2001-11-07       Impact factor: 9.079

2.  Antifungal activity of selective serotonin reuptake inhibitors attributed to non-specific cytotoxicity.

Authors:  T J Young; G P Oliver; D Pryde; M Perros; T Parkinson
Journal:  J Antimicrob Chemother       Date:  2003-03-13       Impact factor: 5.790

3.  Vaginal yeast colonization in nonpregnant women: a longitudinal study.

Authors:  Richard H Beigi; Leslie A Meyn; Donna M Moore; Marijane A Krohn; Sharon L Hillier
Journal:  Obstet Gynecol       Date:  2004-11       Impact factor: 7.661

Review 4.  Anti-Candida activity of essential oils.

Authors:  A Palmeira-de-Oliveira; L Salgueiro; R Palmeira-de-Oliveira; J Martinez-de-Oliveira; C Pina-Vaz; J A Queiroz; A G Rodrigues
Journal:  Mini Rev Med Chem       Date:  2009-10       Impact factor: 3.862

Review 5.  Are plant extracts a potential therapeutic approach for genital infections?

Authors:  A Palmeira-de-Oliveira; B M Silva; R Palmeira-de-Oliveira; J Martinez-de-Oliveira; L Salgueiro
Journal:  Curr Med Chem       Date:  2013       Impact factor: 4.530

6.  Metabolism and disposition of the 5-hydroxytryptamine uptake blocker sertraline in the rat and dog.

Authors:  L M Tremaine; W M Welch; R A Ronfeld
Journal:  Drug Metab Dispos       Date:  1989 Sep-Oct       Impact factor: 3.922

7.  Antifungal properties of selective serotonin reuptake inhibitors against Aspergillus species in vitro.

Authors:  C Lass-Flörl; M P Dierich; D Fuchs; E Semenitz; I Jenewein; M Ledochowski
Journal:  J Antimicrob Chemother       Date:  2001-12       Impact factor: 5.790

8.  Minimum fungicidal concentrations of amphotericin B for bloodstream Candida species.

Authors:  Emilia Cantón; Javier Pemán; Angel Viudes; Guillermo Quindós; Miguel Gobernado; Ana Espinel-Ingroff
Journal:  Diagn Microbiol Infect Dis       Date:  2003-03       Impact factor: 2.803

9.  Antifungal activity of the essential oil of Thymus pulegioides on Candida, Aspergillus and dermatophyte species.

Authors:  Eugénia Pinto; Cidália Pina-Vaz; Lígia Salgueiro; Maria José Gonçalves; Sofia Costa-de-Oliveira; Carlos Cavaleiro; Ana Palmeira; Acácio Rodrigues; José Martinez-de-Oliveira
Journal:  J Med Microbiol       Date:  2006-10       Impact factor: 2.472

10.  Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991-2000.

Authors:  Oscar Marchetti; Jacques Bille; Ursula Fluckiger; Philippe Eggimann; Christian Ruef; Jorge Garbino; Thierry Calandra; Michel-Pierre Glauser; Martin George Täuber; Didier Pittet
Journal:  Clin Infect Dis       Date:  2004-01-14       Impact factor: 9.079
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  3 in total

1.  Anti-Candida activity of antidepressants sertraline and fluoxetine: effect upon pre-formed biofilms.

Authors:  Ana S Oliveira; José Martinez-de-Oliveira; Gilbert G G Donders; Rita Palmeira-de-Oliveira; Ana Palmeira-de-Oliveira
Journal:  Med Microbiol Immunol       Date:  2018-03-19       Impact factor: 3.402

2.  The Synergistic Effect of Azoles and Fluoxetine against Resistant Candida albicans Strains Is Attributed to Attenuating Fungal Virulence.

Authors:  Wenrui Gu; Dongmei Guo; Liuping Zhang; Dongmei Xu; Shujuan Sun
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

Review 3.  Drug repurposing strategies in the development of potential antifungal agents.

Authors:  Qian Zhang; Fangyan Liu; Meng Zeng; Yingyu Mao; Zhangyong Song
Journal:  Appl Microbiol Biotechnol       Date:  2021-06-21       Impact factor: 4.813
  3 in total

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