PURPOSE: This study was designed to assess efficacy and safety in the treatment of perivascular malignant liver lesions using percutaneous, computed tomography (CT)-guided irreversible electroporation (IRE). METHODS: Fourteen patients (mean age 58 ± 11 years) with 18 malignant liver lesions were consecutively enrolled in this study. IRE was performed in patients not eligible for surgery and lesions abutting large vessels or bile ducts. Follow-up exams were performed using multislice-CT (MS-CT) or MRI. RESULTS: Medium lesion diameter was 20 ± 5 mm. Ten of 14 (71 %) were successfully treated with no local recurrence to date (mean follow-up 388 ± 160 days). One case left initial tumor control unclear and additional RFA was performed 4 weeks after IRE. Complications occurred in 4 of 14 (29 %) cases. In one case, intervention was terminated and abdominal bleeding required laparotomy. In two cases, a postinterventional hematothorax required intervention. In another case, abdominal bleeding could be managed conservatively. No complications related to the bile ducts occurred. CONCLUSIONS: Percutaneous IRE seems to be effective in perivascular lesions but is associated with a higher complication rate compared with thermoablative techniques.
PURPOSE: This study was designed to assess efficacy and safety in the treatment of perivascular malignant liver lesions using percutaneous, computed tomography (CT)-guided irreversible electroporation (IRE). METHODS: Fourteen patients (mean age 58 ± 11 years) with 18 malignant liver lesions were consecutively enrolled in this study. IRE was performed in patients not eligible for surgery and lesions abutting large vessels or bile ducts. Follow-up exams were performed using multislice-CT (MS-CT) or MRI. RESULTS: Medium lesion diameter was 20 ± 5 mm. Ten of 14 (71 %) were successfully treated with no local recurrence to date (mean follow-up 388 ± 160 days). One case left initial tumor control unclear and additional RFA was performed 4 weeks after IRE. Complications occurred in 4 of 14 (29 %) cases. In one case, intervention was terminated and abdominal bleeding required laparotomy. In two cases, a postinterventional hematothorax required intervention. In another case, abdominal bleeding could be managed conservatively. No complications related to the bile ducts occurred. CONCLUSIONS: Percutaneous IRE seems to be effective in perivascular lesions but is associated with a higher complication rate compared with thermoablative techniques.
Authors: Natalie Beitel-White; Melvin F Lorenzo; Yajun Zhao; Rebecca M Brock; Sheryl Coutermarsh-Ott; Irving C Allen; Navid Manuchehrabadi; Rafael V Davalos Journal: IEEE Trans Biomed Eng Date: 2021-02-18 Impact factor: 4.538
Authors: René Michael Mathy; Parham Tinoush; Ricardo Daniel da Florencia; Alexander Braun; Omid Ghamarnejad; Boris Radeleff; Hans-Ulrich Kauczor; De-Hua Chang Journal: Sci Rep Date: 2020-12-14 Impact factor: 4.379
Authors: Lea Hitpass; Martina Distelmaier; Ulf P Neumann; Wenzel Schöning; Peter Isfort; Sebastian Keil; Christiane K Kuhl; Philipp Bruners; Alexandra Barabasch Journal: Cardiovasc Intervent Radiol Date: 2021-11-10 Impact factor: 2.740