Literature DB >> 24797432

Akt: a new activation mechanism.

Yuan Gao1, Asad Moten2, Hui-Kuan Lin3.   

Abstract

Akt phosphorylation at S473 and T308 has been believed to be the prerequisites for its activation for years. Now, new phosphorylation event on Akt is identified and can trigger Akt activation and lead to its downstream oncogenic events.

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Year:  2014        PMID： 24797432      PMCID： PMC4085759          DOI： 10.1038/cr.2014.57

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  8 in total

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Authors:  Igor Vivanco; Charles L Sawyers
Journal:  Nat Rev Cancer       Date:  2002-07       Impact factor: 60.716

2.  Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Authors:  D D Sarbassov; David A Guertin; Siraj M Ali; David M Sabatini
Journal:  Science       Date:  2005-02-18       Impact factor: 47.728

3.  Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.

Authors:  Pengda Liu; Michael Begley; Wojciech Michowski; Hiroyuki Inuzuka; Miriam Ginzberg; Daming Gao; Peiling Tsou; Wenjian Gan; Antonella Papa; Byeong Mo Kim; Lixin Wan; Amrik Singh; Bo Zhai; Min Yuan; Zhiwei Wang; Steven P Gygi; Tae Ho Lee; Kun-Ping Lu; Alex Toker; Pier Paolo Pandolfi; John M Asara; Marc W Kirschner; Piotr Sicinski; Lewis Cantley; Wenyi Wei
Journal:  Nature       Date:  2014-03-09       Impact factor: 49.962

4.  The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis.

Authors:  Chia-Hsin Chan; Chien-Feng Li; Wei-Lei Yang; Yuan Gao; Szu-Wei Lee; Zizhen Feng; Hsuan-Ying Huang; Kelvin K C Tsai; Leo G Flores; Yiping Shao; John D Hazle; Dihua Yu; Wenyi Wei; Dos Sarbassov; Mien-Chie Hung; Keiichi I Nakayama; Hui-Kuan Lin
Journal:  Cell       Date:  2012-05-25       Impact factor: 41.582

5.  The E3 ligase TRAF6 regulates Akt ubiquitination and activation.

Authors:  Wei-Lei Yang; Jing Wang; Chia-Hsin Chan; Szu-Wei Lee; Alejandro D Campos; Betty Lamothe; Lana Hur; Brian C Grabiner; Xin Lin; Bryant G Darnay; Hui-Kuan Lin
Journal:  Science       Date:  2009-08-28       Impact factor: 47.728

Review 6.  AKT/PKB signaling: navigating downstream.

Authors:  Brendan D Manning; Lewis C Cantley
Journal:  Cell       Date:  2007-06-29       Impact factor: 41.582

Review 7.  Hallmarks of cancer: the next generation.

Authors:  Douglas Hanahan; Robert A Weinberg
Journal:  Cell       Date:  2011-03-04       Impact factor: 41.582

8.  Akt: a double-edged sword in cell proliferation and genome stability.

Authors:  Naihan Xu; Yuanzhi Lao; Yaou Zhang; David A Gillespie
Journal:  J Oncol       Date:  2012-03-15       Impact factor: 4.375
  8 in total
  8 in total

1.  Cyclin A2 is essential for mouse gonocyte maturation.

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Journal:  Cell Cycle       Date:  2020-05-18       Impact factor: 4.534

2.  Biochemical Effects of Exercise on a Fasciocutaneous Flap in a Rat Model.

Authors:  Edita Aksamitiene; Adam L Baker; Sudeep Roy; Salini Hota; Li-Hui Zhang; Julianna Rodin; Kealan Hobelmann; Jan B Hoek; Edmund A Pribitkin
Journal:  JAMA Facial Plast Surg       Date:  2017-07-01       Impact factor: 4.611

3.  CircRNA circ_0124554 blocked the ubiquitination of AKT promoting the skip lymphovascular invasion on hepatic metastasis in colorectal cancer.

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Journal:  Cell Death Dis       Date:  2021-03-15       Impact factor: 8.469

Review 4.  Dysregulation of mTOR Signaling after Brain Ischemia.

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Journal:  Int J Mol Sci       Date:  2022-03-04       Impact factor: 5.923

5.  Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation.

Authors:  Birgit Lohberger; Andreas Leithner; Nicole Stuendl; Heike Kaltenegger; Werner Kullich; Bibiane Steinecker-Frohnwieser
Journal:  BMC Cancer       Date:  2015-11-10       Impact factor: 4.430

Review 6.  Posttranslational regulation of Akt in human cancer.

Authors:  Chia-Hsin Chan; Ukhyun Jo; Abraham Kohrman; Abdol Hossein Rezaeian; Ping-Chieh Chou; Christopher Logothetis; Hui-Kuan Lin
Journal:  Cell Biosci       Date:  2014-10-01       Impact factor: 7.133

7.  Punicalagin Reversed the Hepatic Injury of Tetrachloromethane by Antioxidation and Enhancement of Autophagy.

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Journal:  J Med Food       Date:  2019-11-12       Impact factor: 2.786

8.  Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22.

Authors:  Miroslava Kacířová; Blanka Železná; Michaela Blažková; Martina Holubová; Andrea Popelová; Jaroslav Kuneš; Blanka Šedivá; Lenka Maletínská
Journal:  J Neuroinflammation       Date:  2021-06-22       Impact factor: 8.322
  8 in total

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