Literature DB >> 24797430

The lock-washer: a reconciliation of the RIG-I activation models.

Shu Zhu1, Ruaidhri Jackson1, Richard A Flavell2.   

Abstract

RIG-I belongs to a type of intracellular pattern recognition receptors involved in the recognition of viral RNA by the innate immune system. A report by Peisley et al. published in Nature provides the crystal structure of human RIG-I revealing a tetrameric architecture of the RIG-I 2-CARD domain bound by three K63-linked ubiquitin chains, uncovering its activation mechanism for downstream signaling.

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Year:  2014        PMID： 24797430      PMCID： PMC4042178          DOI： 10.1038/cr.2014.58

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  9 in total

1.  RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner.

Authors:  Alys Peisley; Bin Wu; Hui Yao; Thomas Walz; Sun Hur
Journal:  Mol Cell       Date:  2013-08-29       Impact factor: 17.970

Review 2.  Mechanisms of MAVS regulation at the mitochondrial membrane.

Authors:  Jana L Jacobs; Carolyn B Coyne
Journal:  J Mol Biol       Date:  2013-10-09       Impact factor: 5.469

3.  Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response.

Authors:  Xiaomo Jiang; Lisa N Kinch; Chad A Brautigam; Xiang Chen; Fenghe Du; Nick V Grishin; Zhijian J Chen
Journal:  Immunity       Date:  2012-06-14       Impact factor: 31.745

4.  Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity.

Authors:  Wenwen Zeng; Lijun Sun; Xiaomo Jiang; Xiang Chen; Fajian Hou; Anirban Adhikari; Ming Xu; Zhijian J Chen
Journal:  Cell       Date:  2010-04-16       Impact factor: 41.582

Review 5.  MasterCARD: a priceless link to innate immunity.

Authors:  John Hiscott; Rongtuan Lin; Peyman Nakhaei; Suzanne Paz
Journal:  Trends Mol Med       Date:  2006-01-06       Impact factor: 11.951

6.  MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.

Authors:  Fajian Hou; Lijun Sun; Hui Zheng; Brian Skaug; Qiu-Xing Jiang; Zhijian J Chen
Journal:  Cell       Date:  2011-07-21       Impact factor: 41.582

7.  TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.

Authors:  Michaela U Gack; Young C Shin; Chul-Hyun Joo; Tomohiko Urano; Chengyu Liang; Lijun Sun; Osamu Takeuchi; Shizuo Akira; Zhijian Chen; Satoshi Inoue; Jae U Jung
Journal:  Nature       Date:  2007-04-19       Impact factor: 49.962

8.  Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I.

Authors:  Alys Peisley; Bin Wu; Hui Xu; Zhijian J Chen; Sun Hur
Journal:  Nature       Date:  2014-03-02       Impact factor: 49.962

Review 9.  Sensing microbial RNA in the cytosol.

Authors:  Nicolas Vabret; J Magarian Blander
Journal:  Front Immunol       Date:  2013-12-25       Impact factor: 7.561
  9 in total
  1 in total

1.  The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity.

Authors:  Karine Doiron; Vanessa Goyon; Etienne Coyaud; Sanjeeva Rajapakse; Brian Raught; Heidi M McBride
Journal:  Sci Rep       Date:  2017-03-07       Impact factor: 4.379
  1 in total

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