| Literature DB >> 16406812 |
John Hiscott1, Rongtuan Lin, Peyman Nakhaei, Suzanne Paz.
Abstract
Intracellular viral infection is detected by the cytoplasmic RNA helicase RIG-I, which has an essential role in initiating the host antiviral response. The adaptor molecule that connects RIG-I sensing of incoming viral RNA to downstream signaling and gene activation has recently been elucidated by four independent research groups, and has been ascribed four different names: MAVS, IPS-1, VISA and Cardif. The fact that MAVS/IPS-1/VISA/Cardif localizes to the mitochondrial membrane suggests a link between viral infection, mitochondrial function and development of innate immunity. Furthermore, the hepatitis C virus NS3/4A protease specifically cleaves MAVS/IPS-1/VISA/Cardif as part of its immune-evasion strategy. These studies highlight a novel role for the mitochondria and for caspase activation and recruitment domain (CARD)-containing proteins in coordinating immune and apoptotic responses.Entities:
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Year: 2006 PMID： 16406812 DOI： 10.1016/j.molmed.2005.12.003
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951