Literature DB >> 2479575

Prothymosin alpha is an evolutionary conserved protein covalently linked to a small RNA.

T Makarova1, N Grebenshikov, C Egorov, A Vartapetian, A Bogdanov.   

Abstract

A 13 kDa protein, covalently linked to a small RNA from the cytoplasm of mouse cells, was studied. Sequence analysis of its tryptic peptides revealed that the RNA-linked protein is identical to prothymosin alpha. Very similar RNA-protein complexes were identified in human, bovine and yeast cells. Tryptic peptide maps of 125I-labelled RNA-linked proteins of diverse origin demonstrated their marked similarity, thus indicating high evolutionary conservation of prothymosin alpha from yeast to man.

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Year:  1989        PMID： 2479575     DOI： 10.1016/0014-5793(89)81544-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

1.  Evidence for the extranuclear localization of thymosins in thymus.

Authors:  O E Tsitsiloni; P P Yialouris; H Echner; W Voelter; A A Haritos
Journal:  Experientia       Date:  1992-04-15

2.  Evidence for nuclear targeting of prothymosin and parathymosin synthesized in situ.

Authors:  M Clinton; L Graeve; H el-Dorry; E Rodriguez-Boulan; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-01       Impact factor: 11.205

3.  Cellular levels of thymosin immunoreactive peptides are linked to proliferative events: evidence for a nuclear site of action.

Authors:  C N Conteas; M G Mutchnick; K C Palmer; F E Weller; G D Luk; P H Naylor; M R Erdos; A L Goldstein; C Panneerselvam; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

4.  Identification of estrogen-responsive genes in neuroblastoma SK-ER3 cells.

Authors:  M Garnier; D Di Lorenzo; A Albertini; A Maggi
Journal:  J Neurosci       Date:  1997-06-15       Impact factor: 6.167

5.  Overexpression of prothymosin alpha accelerates proliferation and retards differentiation in HL-60 cells.

Authors:  P Rodríguez; J E Viñuela; L Alvarez-Fernández; M Buceta; A Vidal; F Domínguez; J Gómez-Márquez
Journal:  Biochem J       Date:  1998-05-01       Impact factor: 3.857

6.  Immunohistochemical location of prothymosin alpha in regenerating human hepatocytes and hepatocellular carcinomas.

Authors:  M Fraga; T García-Caballero; F Domínguez; E Pérez-Becerra; A Beiras; J Forteza
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1993

7.  The metastatic suppressor Nm23-H1 interacts with EBNA3C at sequences located between the glutamine- and proline-rich domains and can cooperate in activation of transcription.

Authors:  Chitra Subramanian; Erle S Robertson
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

8.  Prothymosin alpha modulates the interaction of histone H1 with chromatin.

Authors:  Z Karetsou; R Sandaltzopoulos; M Frangou-Lazaridis; C Y Lai; O Tsolas; P B Becker; T Papamarcaki
Journal:  Nucleic Acids Res       Date:  1998-07-01       Impact factor: 16.971

9.  Prothymosin alpha antisense oligomers inhibit myeloma cell division.

Authors:  A R Sburlati; R E Manrow; S L Berger
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-01       Impact factor: 11.205

10.  Prothymosin alpha gene in humans: organization of its promoter region and localization to chromosome 2.

Authors:  P Szabo; C Panneerselvam; M Clinton; M Frangou-Lazaridis; D Weksler; E Whittington; M J Macera; K H Grzeschik; A Selvakumar; B L Horecker
Journal:  Hum Genet       Date:  1993-02       Impact factor: 4.132
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