Nischay Mishra1, Marcus Pereira2, Roy H Rhodes3, Ping An4, James M Pipas4, Komal Jain1, Amit Kapoor1, Thomas Briese1, Phyllis L Faust5, W Ian Lipkin1. 1. Center for Infection and Immunity. 2. Division of Infectious Diseases, Columbia University, New York, New York. 3. Pathology and Laboratory Medicine, Rutgers University, New Brunswick, New Jersey. 4. Department of Biological Sciences, University of Pittsburgh, Pennsylvania. 5. Pathology and Cell Biology, Columbia University, New York, New York.
Abstract
BACKGROUND: A 33 year-old pancreatic transplant recipient developed weakness, retinal blindness, and necrotic plaques on her face, scalp, and hands. METHODS: A muscle biopsy was analyzed by light and electron microscopy and high-throughput nucleic acid sequencing. RESULTS: The biopsy revealed microthrombosis and viral particles in swollen endothelial cell nuclei. High-throughput sequencing of nucleic acid revealed a novel polyomavirus. In situ hybridization confirmed the presence of the polyomavirus in endothelial cells at sites of myositis and cutaneous necrosis. CONCLUSIONS: New Jersey polyomavirus (NJPyV-2013) is a novel polyomavirus that may have tropism for vascular endothelial cells.
BACKGROUND: A 33 year-old pancreatic transplant recipient developed weakness, retinal blindness, and necrotic plaques on her face, scalp, and hands. METHODS: A muscle biopsy was analyzed by light and electron microscopy and high-throughput nucleic acid sequencing. RESULTS: The biopsy revealed microthrombosis and viral particles in swollen endothelial cell nuclei. High-throughput sequencing of nucleic acid revealed a novel polyomavirus. In situ hybridization confirmed the presence of the polyomavirus in endothelial cells at sites of myositis and cutaneous necrosis. CONCLUSIONS: New Jersey polyomavirus (NJPyV-2013) is a novel polyomavirus that may have tropism for vascular endothelial cells.
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