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Literature DB >> 24792889

Shaping of NK cell subsets by aging.

Rafael Solana¹, Carmen Campos², Alejandra Pera², Raquel Tarazona³.

Abstract

NK cells are key players in the innate immune response against virus infection and tumors. Here we describe the current knowledge on age-associated changes in NK cells and the role of persistent CMV infection in configuring NK cell compartment in the elderly. Aging but not CMV causes a redistribution of NK cell subsets as shown by a decrease of CD56bright cells and an increase of CD56-CD16+ NK cells. On the contrary the changes in CD56dimCD16+ NK cells are compatible with the accumulation of CD57+ long-lived NK cells that can also be observed in young CMV-seropositive individuals. NK cell function and dynamics in the elderly will be related not only with age but also with exposure to pathogens, especially CMV.

Entities: Disease Gene

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Year: 2014 PMID： 24792889 DOI： 10.1016/j.coi.2014.04.002

Source DB: PubMed Journal: Curr Opin Immunol ISSN： 0952-7915 Impact factor: 7.486

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Cited

46 in total

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Journal: Immunity Date: 2015-12-15 Impact factor: 31.745

2. Characterization of a human anti-tumoral NK cell population expanded after BCG treatment of leukocytes.

Authors: Eva M García-Cuesta; Gloria Esteso; Omodele Ashiru; Sheila López-Cobo; Mario Álvarez-Maestro; Ana Linares; Mei M Ho; Luis Martínez-Piñeiro; Hugh T Reyburn; Mar Valés-Gómez
Journal: Oncoimmunology Date: 2017-02-21 Impact factor: 8.110

Review 3. Intracellular signalling pathways: targets to reverse immunosenescence.

Authors: T Fulop; J M Witkowski; A Le Page; C Fortin; G Pawelec; A Larbi
Journal: Clin Exp Immunol Date: 2016-08-03 Impact factor: 4.330

4. Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing.

Authors: Samantha L Smith; Philippa R Kennedy; Kevin B Stacey; Jonathan D Worboys; Annie Yarwood; Seungmae Seo; Everardo Hegewisch Solloa; Brandon Mistretta; Sujash S Chatterjee; Preethi Gunaratne; Kimaada Allette; Ying-Chih Wang; Melissa Laird Smith; Robert Sebra; Emily M Mace; Amir Horowitz; Wendy Thomson; Paul Martin; Steve Eyre; Daniel M Davis
Journal: Blood Adv Date: 2020-04-14

5. Age- and Sex-associated Differences in Phenotypic and Functional Characteristics of Peripheral Blood Lymphocytes in Chimpanzees (Pan troglodytes).

Authors: Pramod N Nehete; Elizabeth R Magden; Bharti P Nehete; Lawrence E Williams; Christian R Abee; K Jagannadha Sastry
Journal: J Am Assoc Lab Anim Sci Date: 2017-09-01 Impact factor: 1.232

10. A longitudinal study of the stability, variability, and interdependencies among late-differentiated T and NK cell subsets in older adults.

Authors: Rebecca G Reed; Ahmad Al-Attar; Steven R Presnell; Charles T Lutz; Suzanne C Segerstrom
Journal: Exp Gerontol Date: 2019-03-15 Impact factor: 4.032

Shaping of NK cell subsets by aging.

1. Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures.

2. Characterization of a human anti-tumoral NK cell population expanded after BCG treatment of leukocytes.

Review 3. Intracellular signalling pathways: targets to reverse immunosenescence.

4. Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing.

5. Age- and Sex-associated Differences in Phenotypic and Functional Characteristics of Peripheral Blood Lymphocytes in Chimpanzees (Pan troglodytes).

6. Natural killer cells phenotypic characterization as an outcome predictor of HCV-linked HCC after curative treatments.

Review 7. Role of Immune Aging in Susceptibility to West Nile Virus.

Review 8. Age-related alterations in immune responses to West Nile virus infection.

Review 9. Assessing immune aging in HIV-infected patients.

10. A longitudinal study of the stability, variability, and interdependencies among late-differentiated T and NK cell subsets in older adults.