| Literature DB >> 27188562 |
Abstract
West Nile virus (WNV) can cause severe neuroinvasive disease in humans and currently no vaccine or specific treatments are available. As aging is the most prominent risk factor for WNV, age-related immune dysregulation likely plays an essential role in host susceptibility to infection with WNV. In this review, we summarize recent findings in effects of aging on immune responses to WNV infection. In particular, we focus on the age-dependent dysregulation of innate immune cell types-neutrophils, macrophages, and dendritic cells-in response to WNV infection, as well as age-related alterations in NK cells and γδ T cells that may associate with increased WNV susceptibility in older people. We also highlight two advanced technologies, i.e., mass cytometry and microRNA profiling, which significantly contribute to systems-level study of immune dysregulation in aging and should facilitate new discoveries for therapeutic intervention against WNV.Entities:
Keywords: Aging; Immune aging; Mass cytometry; MicroRNAs; West Nile virus
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Year: 2016 PMID： 27188562 PMCID： PMC4941816 DOI： 10.1007/978-1-4939-3670-0_18
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745