| Literature DB >> 24791030 |
Abstract
A convenient and efficient (one-step) oxidation is reported of commercially available tosylmethylisocyanide (TOSMIC) to form tosylmethylisocyanate, making this highly reactive bifunctional molecule a readily available synthetic reagent. Besides engaging in nucleophilic addition reactions with alcohols, amines and thiols, tosylmethylisocyanate also reacts with carboxylic acids to form tosylmethylamides, which undergo substitution reactions in the presence of organocopper and organomagnesium reagents.Entities:
Keywords: Isonitrile-based Multicomponent reactions; Tosylmethylamide; Tosylmethylisocyanate; Tosylmethylisocyanide; p-Toluenesulfonylmethyl isocyanate
Year: 2014 PMID： 24791030 PMCID： PMC4001987 DOI： 10.1016/j.tetlet.2014.02.016
Source DB: PubMed Journal: Tetrahedron Lett ISSN： 0040-4039 Impact factor: 2.415