| Literature DB >> 21491899 |
Abstract
A smooth and efficient oxidation of isonitriles to isocyanates by sulfoxides is catalyzed by trifluoroacetic anhydride. With use of DMSO as the oxidant and 5 mol·% TFAA (dichloromethane, -60 to 0 °C), the process is complete in a few minutes, forming dimethyl sulfide as the only byproduct. The newly formed isocyanates may be used directly or isolated in high purity by solvent evaporation.Entities:
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Year: 2011 PMID： 21491899 PMCID： PMC3102642 DOI： 10.1021/ol200695y
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005