Literature DB >> 24789192

Breakthrough invasive Candida glabrata in patients on micafungin: a novel FKS gene conversion correlated with sequential elevation of MIC.

Takeshi Saraya1, Koichi Tanabe2, Koji Araki3, Shota Yonetani3, Hiroshi Makino3, Takayasu Watanabe4, Naoki Tsujimoto4, Saori Takata4, Daisuke Kurai4, Haruyuki Ishii4, Yoshitsugu Miyazaki2, Hajime Takizawa4, Hajime Goto4.   

Abstract

Candida glabrata strains sequentially isolated from blood developed resistance to micafungin (MICs from <0.015 to 4 μg/ml). A novel mutation identified in micafungin-resistant strains at bp 262 of FKS2 (containing a deletion of F659 [F659del]) was inserted into the homologous region in FKS1.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24789192      PMCID： PMC4097732          DOI： 10.1128/JCM.03593-13

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  13 in total

1.  Frequency of fks mutations among Candida glabrata isolates from a 10-year global collection of bloodstream infection isolates.

Authors:  Mariana Castanheira; Leah N Woosley; Shawn A Messer; Daniel J Diekema; Ronald N Jones; Michael A Pfaller
Journal:  Antimicrob Agents Chemother       Date:  2013-10-14       Impact factor: 5.191

2.  DNA polymorphisms amplified by arbitrary primers are useful as genetic markers.

Authors:  J G Williams; A R Kubelik; K J Livak; J A Rafalski; S V Tingey
Journal:  Nucleic Acids Res       Date:  1990-11-25       Impact factor: 16.971

Review 3.  Resistance to echinocandin-class antifungal drugs.

Authors:  David S Perlin
Journal:  Drug Resist Updat       Date:  2007-06-13       Impact factor: 18.500

4.  Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility.

Authors:  Santosh Katiyar; Michael Pfaller; Thomas Edlind
Journal:  Antimicrob Agents Chemother       Date:  2006-08       Impact factor: 5.191

5.  FKS mutations and elevated echinocandin MIC values among Candida glabrata isolates from U.S. population-based surveillance.

Authors:  Alicia J Zimbeck; Naureen Iqbal; Angela M Ahlquist; Monica M Farley; Lee H Harrison; Tom Chiller; Shawn R Lockhart
Journal:  Antimicrob Agents Chemother       Date:  2010-09-13       Impact factor: 5.191

6.  [A case of micafungin-hyposensitive Candida glabrata due to FKS2 gene mutation].

Authors:  Sachiko Inui; Tatsuya Nakamura; Kouichi Tanabe; Hideaki Ohno; Chihiro Koike; Kazuyuki Okuda; Chiyo Nakata; Hiroko Fujimoto; Hiroe Ohkura; Yoshitsugu Miyazaki; Hakuo Takahashi
Journal:  Kansenshogaku Zasshi       Date:  2011-01

7.  Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression.

Authors:  Kyoko Niimi; Matthew A Woods; Katsuyuki Maki; Hironobu Nakayama; Kazuaki Hatakenaka; Hiroji Chibana; Fumiaki Ikeda; Keigo Ueno; Masakazu Niimi; Richard D Cannon; Brian C Monk
Journal:  J Antimicrob Chemother       Date:  2012-04-18       Impact factor: 5.790

8.  Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint.

Authors:  Guillermo Garcia-Effron; Samuel Lee; Steven Park; John D Cleary; David S Perlin
Journal:  Antimicrob Agents Chemother       Date:  2009-06-22       Impact factor: 5.191

9.  Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America.

Authors:  Peter G Pappas; Carol A Kauffman; David Andes; Daniel K Benjamin; Thierry F Calandra; John E Edwards; Scott G Filler; John F Fisher; Bart-Jan Kullberg; Luis Ostrosky-Zeichner; Annette C Reboli; John H Rex; Thomas J Walsh; Jack D Sobel
Journal:  Clin Infect Dis       Date:  2009-03-01       Impact factor: 9.079

10.  Candida spp. with acquired echinocandin resistance, France, 2004-2010.

Authors:  Eric Dannaoui; Marie Desnos-Ollivier; Dea Garcia-Hermoso; Fredéric Grenouillet; Sophie Cassaing; Marie-Thérèse Baixench; Stéphane Bretagne; Françoise Dromer; Olivier Lortholary
Journal:  Emerg Infect Dis       Date:  2012-01       Impact factor: 6.883
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  10 in total

1.  Amphotericin B Induction with Voriconazole Consolidation as Salvage Therapy for FKS-Associated Echinocandin Resistance in Candida glabrata Septic Arthritis and Osteomyelitis.

Authors:  William F Wright; Nika Bejou; Ryan K Shields; Kieren Marr; Todd P McCarty; Peter G Pappas
Journal:  Antimicrob Agents Chemother       Date:  2019-07-25       Impact factor: 5.191

2.  Development of Echinocandin Resistance in Candida tropicalis following Short-Term Exposure to Caspofungin for Empiric Therapy.

Authors:  Ziauddin Khan; Suhail Ahmad; Eiman Mokaddas; Jacques F Meis; Leena Joseph; Aneesa Abdullah; Sandhya Vayalil
Journal:  Antimicrob Agents Chemother       Date:  2018-03-27       Impact factor: 5.191

3.  Antifungal de-escalation was not associated with adverse outcome in critically ill patients treated for invasive candidiasis: post hoc analyses of the AmarCAND2 study data.

Authors:  Sébastien Bailly; Olivier Leroy; Philippe Montravers; Jean-Michel Constantin; Hervé Dupont; Didier Guillemot; Olivier Lortholary; Jean-Paul Mira; Pierre-François Perrigault; Jean-Pierre Gangneux; Elie Azoulay; Jean-François Timsit
Journal:  Intensive Care Med       Date:  2015-09-14       Impact factor: 17.440

4.  Clinical and Microbiological Characteristics of Breakthrough Candidemia in Allogeneic Hematopoietic Stem Cell Transplant Recipients in a Japanese Hospital.

Authors:  Muneyoshi Kimura; Hideki Araoka; Hisashi Yamamoto; Yuki Asano-Mori; Shigeki Nakamura; Satoshi Yamagoe; Hideaki Ohno; Yoshitsugu Miyazaki; Masahiro Abe; Mitsuhiro Yuasa; Daisuke Kaji; Kosei Kageyama; Aya Nishida; Kazuya Ishiwata; Shinsuke Takagi; Go Yamamoto; Naoyuki Uchida; Koji Izutsu; Atsushi Wake; Shuichi Taniguchi; Akiko Yoneyama
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

5.  ERG6 and ERG2 Are Major Targets Conferring Reduced Susceptibility to Amphotericin B in Clinical Candida glabrata Isolates in Kuwait.

Authors:  Suhail Ahmad; Leena Joseph; Josie E Parker; Mohammad Asadzadeh; Steven L Kelly; Jacques F Meis; Ziauddin Khan
Journal:  Antimicrob Agents Chemother       Date:  2019-01-29       Impact factor: 5.191

6.  Lack of detection of Candida nivariensis and Candida bracarensis among 440 clinical Candida glabrata sensu lato isolates in Kuwait.

Authors:  Mohammad Asadzadeh; Ahlam F Alanazi; Suhail Ahmad; Noura Al-Sweih; Ziauddin Khan
Journal:  PLoS One       Date:  2019-10-16       Impact factor: 3.240

7.  Analysis of antifungal resistance genes in Candida albicans and Candida glabrata using next generation sequencing.

Authors:  Kathrin Spettel; Wolfgang Barousch; Athanasios Makristathis; Iris Zeller; Marion Nehr; Brigitte Selitsch; Michaela Lackner; Peter-Michael Rath; Joerg Steinmann; Birgit Willinger
Journal:  PLoS One       Date:  2019-01-10       Impact factor: 3.240

8.  Antifungal drug susceptibility, molecular basis of resistance to echinocandins and molecular epidemiology of fluconazole resistance among clinical Candida glabrata isolates in Kuwait.

Authors:  Zahraa F Al-Baqsami; Suhail Ahmad; Ziauddin Khan
Journal:  Sci Rep       Date:  2020-04-10       Impact factor: 4.379

9.  In Vitro Characterization of Twenty-One Antifungal Combinations against Echinocandin-Resistant and -Susceptible Candida glabrata.

Authors:  Hazim O Khalifa; Hidetaka Majima; Akira Watanabe; Katsuhiko Kamei
Journal:  J Fungi (Basel)       Date:  2021-02-02

10.  Fatal Breakthrough Candidemia in an Immunocompromised Patient in Kuwait Due to Candida auris Exhibiting Reduced Susceptibility to Echinocandins and Carrying a Novel Mutation in Hotspot-1 of FKS1.

Authors:  Inaam Al-Obaid; Mohammad Asadzadeh; Suhail Ahmad; Khaled Alobaid; Wadha Alfouzan; Ritu Bafna; Maha Emara; Leena Joseph
Journal:  J Fungi (Basel)       Date:  2022-03-06
  10 in total

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