Literature DB >> 2478515

Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures.

T Iida1, E Kobayashi, M Yoshida, H Sano.   

Abstract

The structures of new antitumor antibiotics, calphostins (UCN-1028) A, B, C, D and I, which are specific and potent inhibitors of protein kinase C, were determined by spectral and chemical studies. All of the antibiotics have a 3,10-perylenequinone skeleton and calphostin D was revealed to be an antipode of isophleichrome.

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Year:  1989        PMID： 2478515     DOI： 10.7164/antibiotics.42.1475

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  8 in total

1.  Carbene Complexes in the Synthesis of Complex Natural Products: Total Synthesis of the Calphostins.

Authors:  Craig A Merlic; Courtney C Aldrich; Jennifer Albaneze-Walker; Alan Saghatelian
Journal:  J Am Chem Soc       Date:  2000-04-05       Impact factor: 15.419

2.  Perylenequinone natural products: total syntheses of the diastereomers (+)-phleichrome and (+)-calphostin D by assembly of centrochiral and axial chiral fragments.

Authors:  Barbara J Morgan; Carol A Mulrooney; Erin M O'Brien; Marisa C Kozlowski
Journal:  J Org Chem       Date:  2010-01-01       Impact factor: 4.354

3.  Design, synthesis, and investigation of protein kinase C inhibitors: total syntheses of (+)-calphostin D, (+)-phleichrome, cercosporin, and new photoactive perylenequinones.

Authors:  Barbara J Morgan; Sangeeta Dey; Steven W Johnson; Marisa C Kozlowski
Journal:  J Am Chem Soc       Date:  2009-07-08       Impact factor: 15.419

4.  Pentoxifylline and other protein kinase C inhibitors down-regulate HIV-LTR NF-kappa B induced gene expression.

Authors:  D K Biswas; C M Ahlers; B J Dezube; A B Pardee
Journal:  Mol Med       Date:  1994-11       Impact factor: 6.354

5.  Perylenequinones: Isolation, Synthesis, and Biological Activity.

Authors:  Carol A Mulrooey; Erin M O'Brien; Barbara J Morgan; Marisa C Kozlowski
Journal:  European J Org Chem       Date:  2012-07-01

Review 6.  Fungal perylenequinones.

Authors:  Afra Khiralla; Aisha Ohag Mohammed; Sakina Yagi
Journal:  Mycol Prog       Date:  2022-04-04       Impact factor: 2.538

Review 7.  The Genus Cladosporium: A Rich Source of Diverse and Bioactive Natural Compounds.

Authors:  Maria Michela Salvatore; Anna Andolfi; Rosario Nicoletti
Journal:  Molecules       Date:  2021-06-28       Impact factor: 4.411

8.  PKC and PKA regulate AChR dynamics at the neuromuscular junction of living mice.

Authors:  Isabel Martinez-Pena y Valenzuela; Marcelo Pires-Oliveira; Mohammed Akaaboune
Journal:  PLoS One       Date:  2013-11-15       Impact factor: 3.240
  8 in total

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