Literature DB >> 2478514

Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities.

E Kobayashi1, K Ando, H Nakano, T Iida, H Ohno, M Morimoto, T Tamaoki.   

Abstract

A novel complex of calphostin (UCN-1028), which specifically inhibits protein kinase C (PKC) has been isolated from the culture broth of a fungi Cladosporium cladosporioides. Purification of individual components was carried out by silica gel, non-porus resin Diaion HP-20SS and Sephadex LH-20 chromatography, leading to isolation of five closely related components. A, B, C, D and I. Calphostins showed cytotoxic activities against various tumor cells, and these cytotoxicities were proportional to their inhibitory activities against PKC.

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Year:  1989        PMID： 2478514     DOI： 10.7164/antibiotics.42.1470

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  25 in total

1.  Pharmacokinetic features and metabolism of calphostin C, a naturally occurring perylenequinone with antileukemic activity.

Authors:  C L Chen; H L Tai; D M Zhu; F M Uckun
Journal:  Pharm Res       Date:  1999-07       Impact factor: 4.200

Review 2.  Side-effects of protein kinase inhibitors on ion channels.

Authors:  Youn Kyoung Son; Hongzoo Park; Amy L Firth; Won Sun Park
Journal:  J Biosci       Date:  2013-12       Impact factor: 1.826

3.  Dopamine-dependent tuning of striatal inhibitory synaptogenesis.

Authors:  Darren Goffin; Afia B Ali; Nazir Rampersaud; Alexander Harkavyi; Celine Fuchs; Peter S Whitton; Angus C Nairn; Jasmina N Jovanovic
Journal:  J Neurosci       Date:  2010-02-24       Impact factor: 6.167

4.  Carbene Complexes in the Synthesis of Complex Natural Products: Total Synthesis of the Calphostins.

Authors:  Craig A Merlic; Courtney C Aldrich; Jennifer Albaneze-Walker; Alan Saghatelian
Journal:  J Am Chem Soc       Date:  2000-04-05       Impact factor: 15.419

Review 5.  Mechanisms of resistance to photodynamic therapy.

Authors:  A Casas; G Di Venosa; T Hasan
Journal:  Curr Med Chem       Date:  2011       Impact factor: 4.530

6.  α1 -Adrenoceptor activation of PKC-ε causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats.

Authors:  Yingzi Zhao; Paul M Vanhoutte; Susan W S Leung
Journal:  Br J Pharmacol       Date:  2015-05-15       Impact factor: 8.739

7.  Oxycodone-induced tolerance to respiratory depression: reversal by ethanol, pregabalin and protein kinase C inhibition.

Authors:  Rob Hill; William L Dewey; Eamonn Kelly; Graeme Henderson
Journal:  Br J Pharmacol       Date:  2018-05-07       Impact factor: 8.739

8.  Participation of protein kinase C in endothelin-1-induced contraction in rat aorta: studies with a new tool, calphostin C.

Authors:  H Shimamoto; Y Shimamoto; C Y Kwan; E E Daniel
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739

9.  Protein kinase C modulates synaptic vesicle acidification in a ribbon type nerve terminal in the retina.

Authors:  Bento J Abreu; Maila Guimarães; Livia C Uliana; Jozsef Vigh; Henrique von Gersdorff; Marco A Prado; Cristina Guatimosim
Journal:  Neurochem Int       Date:  2008-07-22       Impact factor: 3.921

10.  Identification of potentially safe promising fungal cell factories for the production of polyketide natural food colorants using chemotaxonomic rationale.

Authors:  Sameer As Mapari; Anne S Meyer; Ulf Thrane; Jens C Frisvad
Journal:  Microb Cell Fact       Date:  2009-04-27       Impact factor: 5.328
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