| Literature DB >> 24780392 |
Hildegard T Greinix1, Nina Worel2, Ulrike Just3, Robert Knobler3.
Abstract
Graft-versus-host disease (GvHD) is a serious complication of allogeneic hematopoietic cell transplantation causing significant morbidity and mortality. Corticosteroids are the established first-line treatment of GvHD. Patients not responding to corticosteroids have a dismal prognosis. Extracorporeal photopheresis (ECP) has objective activity in the treatment of both acute and chronic corticosteroid-refractory GvHD patients, has an excellent safety profile and is internationally well-established. ECP has been recommended by a significant number of renowned scientific organizations as an efficient treatment option for patients with GvHD. ECP has a proven corticosteroid-sparing effect and favourably impacts on survival and quality of life of responding patients.Entities:
Keywords: Extracorporeal photopheresis; Graft-versus-host disease
Mesh:
Year: 2014 PMID: 24780392 DOI: 10.1016/j.transci.2014.04.005
Source DB: PubMed Journal: Transfus Apher Sci ISSN: 1473-0502 Impact factor: 1.764