Literature DB >> 24779517

Shagenes A and B, new tricyclic sesquiterpenes produced by an undescribed Antarctic octocoral.

Jacqueline L von Salm1, Nerida G Wilson, Brian A Vesely, Dennis E Kyle, Jason Cuce, Bill J Baker.   

Abstract

The isolation and characterization of two new tricyclic sesquiterpenoids, shagenes A (1) and B (2) are presented. These compounds were isolated from an undescribed soft coral collected from the Scotia Arc in the Southern Ocean. One- and two-dimensional NMR spectroscopy and mass spectrometry provided the data necessary to characterize the compounds and their relative stereochemical configurations. Exploration of the bioactivity of shagenes A and B found 1 active against the visceral leishmaniasis causing parasite, Leishmania donovani, with no cytotoxicity against the mammalian host.

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Year:  2014        PMID： 24779517      PMCID： PMC4127331          DOI： 10.1021/ol500792x

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  11 in total

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Review 2.  Cold-water marine natural products.

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5.  Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: the first natural nitrate esters.

Authors:  J A Palermo; M F Brasco; C Spagnuolo; A M Seldes
Journal:  J Org Chem       Date:  2000-07-28       Impact factor: 4.354

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Journal:  J Nat Prod       Date:  2003-06       Impact factor: 4.050

9.  An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages.

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  10 in total

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Review 6.  Total syntheses of strained polycyclic terpenes.

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7.  Chemistry and Bioactivity of the Deep-Water Antarctic Octocoral Alcyonium sp.

Authors:  Anne-Claire D Limon; Hiran M L W Patabendige; Ala Azhari; Xingmin Sun; Dennis E Kyle; Nerida G Wilson; Bill J Baker
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8.  Antimicrobial Activity of Monoramnholipids Produced by Bacterial Strains Isolated from the Ross Sea (Antarctica).

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Journal:  Mar Drugs       Date:  2016-04-26       Impact factor: 5.118

Review 9.  Marine Terpenoids from Polar Latitudes and Their Potential Applications in Biotechnology.

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10.  Exploitation of Mangrove Endophytic Fungi for Infectious Disease Drug Discovery.

Authors:  Danielle H Demers; Matthew A Knestrick; Renee Fleeman; Rahmy Tawfik; Ala Azhari; Ashley Souza; Brian Vesely; Mandy Netherton; Rashmi Gupta; Beatrice L Colon; Christopher A Rice; Mario A Rodríguez-Pérez; Kyle H Rohde; Dennis E Kyle; Lindsey N Shaw; Bill J Baker
Journal:  Mar Drugs       Date:  2018-10-10       Impact factor: 5.118
  10 in total

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